Description
Cushing Syndrome: History, Diagnosis, and Treatment is written by top experts on the latest in genetics, molecular advances, and the diagnosis and treatment of Cushing syndrome. The book takes a historical approach to discuss the tremendous and unprecedented research development for this rare condition and includes information on recently approved treatments. It attempts to provide information on most issues surrounding Cushing syndrome and how to deal with its complications, the widening understanding of functional hypercortisolemia and other causes of endogenous cortisol production and its old and new treatment modalities, from pituitary to adrenal tumors, ectopic ACTH production, subclinical, cyclical Cushing syndrome, to aging and metabolic syndrome.The book has a section dedicated to our patients with the patients' experiences, which will add to the outcome research presented by the physicians. This is a must have reference for scientists and researchers with the latest information in diagnosing and treating this difficult-to-diagnose and difficult-to-treat condition and gives the clinician, a patient-centric approach to communicate with this particular group of patients.- Provides comprehensive "how to" information for diagnosis and treatment- Includes the latest information on genetics, all molecular advances, and new medical therapies- Presents a patient-centric approach with an emphasis on patients' perspectives and long-term effects of cortisol excess, well-being, and mental health
Table of Contents
1. Identification of Cushing syndrome (CS) and its history from Harvey Cushing to today2. Exogenous CS (iatrogenic): most frequent uses of glucocorticoids and outcomes, including recommendations for recovery (post-chemotherapy, asthma treatments, chronic use on rheumatoid and/or skeletal disorders)3. Endogenous CS: causes and genetics4. CS and malingering: Munchausen syndrome and Muncausen-by-proxy: cases, diagnosis, and outcomes5. Non-tumorous functional hypercortisolemia (pseudo-CS): causes and long-term issues6. Cushing disease: pituitary tumors causing CS: genetics, molecular advances, diagnosis, and treatment7. Inferior Petrosal Sinus Sampling: to do or not to do8. CRH test: to do or not to do9. All about dexamethasone testing in CS10. ACTH-independent CS: adrenal tumors causing CS: genetics, molecular advances, diagnosis, and treatment11. Ectopic ACTH or CRH-producing tumors and CS: genetics, syndromes, molecular advances, diagnosis, and treatment12. Animal models of CS: what do they teach us?13. Medical therapies for CS14. Surgical issues for a patient with CS: techniques, complications, and recovery15. The patient with CS: perspectives written by patients; resources for patients16. Cortisol exposure and mental health17. CS and long-term effects on health, cognition, and function
