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Description
The field of rheumatology has undergone numerous exciting advances in recent years, especially the development of biological drugs with novel targets, made possible by rapid advances in the basic science of musculoskeletal diseases together with improved imaging techniques. This thoroughly revised fourth edition of the Oxford Textbook of Rheumatology reflects the changing face of the specialty and the many recent advances in the science, treatment, and understanding of rheumatic diseases. The focus of this comprehensive reference work is the presentation and management of rheumatic conditions at all ages. Where relevant, treatment approaches are evidence-based and cross-referenced to national and international guidelines. Each clinical chapter provides up-to-date treatment advice illustrated with clinical vignettes as appropriate, and the authors consistently emphasize the overlap of rheumatology with other disciplines. With full colour illustrations throughout and a complementary online version, the Oxford Textbook of Rheumatology, Fourth Edition is an essential reference for all trainees and specialists in the field.
Table of Contents
- Section 1 Clinical presentations of rheumatic disease in different age groups
- 1: Lori Tucker: The child patient
- 2: Janet E. McDonagh: Young people and transitional care in rheumatology
- 3: Paul Thompson: The adult patient
- 4: Fraser Birrell: The elderly patient
- 5: Helen Foster: Principles of clinical examination in children
- 6: Lesley Kay: Principles of clinical examination in adults
- Section 2 Common clinical problems of rheumatic disease
- 7: Marc Lillicrap: Monoarticular disease
- 8: Andrew Keat: Oligoarticular disease
- 9: Ade Adebajo: Polyarticular disease
- 10: Raashid Luqmani: The systemically ill patient
- 11: Karl Gaffney: Spinal pain
- 12: Candy McCabe and Helen Cohen: Pain and Fatigue
- 13: Yuki Kimura: The limping child
- 14: Athimalaipet Ramanan: The systemically unwell child
- 15: Elspeth Wise: Primary care presentation
- Section 3 Clinical presentations: Views from different perspectives
- 16: Monika Oestensen: Obstetrics and pregnancy
- 17: Christopher Griffiths: The skin
- 18: Andrew Graham and Clare Galton: The nervous system
- 19: Gerry Coghlan: The cardiovascular system
- 20: The respiratory system
- 21: Gerhard Rogler: The gastrointestinal system
- 22: Rainer Straub: The neuroendocrine system
- 23: Clive Kelly: Malignancy
- 24: Miles Stanford: The eye
- 25: Mark Little: The kidney
- 26: Stanton Newman: Psychology
- Section 4 The impact of rheumatic disease
- 27: Deborah Symmons: Epidemiology of rheumatic diseases
- 28: Piet van Riel: Assessment of rheumatic disease
- 29: David L. Scott: Outcomes
- 30: Vibeke Strand: Design of clinical trials in rheumatology
- 31: Sonja Merkesdal and Wilfried Mau: Health economics
- 32: Tuulikki Sokka: Co-morbidities of rheumatic disease
- 33: Ross Wilkie: Social aspects (work)
- 34: David Isenberg and Angela Zink: Biologics registries
- 35: Kirsten Minden: Outcomes of paediatric rheumatic disease
- 36: Ciaran Duffy: Assessment of paediatric rheumatic disease
- Section 5 Genetics and environment
- 37: Anne Barton: Basics of genetics
- 38: Cyrus Cooper: Environment
- 39: Steffen Gay and Michel Neidhart: Epigenetics
- 40: Sebastien Viatte: Genetics of rheumatoid arthritis
- 41: Matthew Brown: Genetics of Spondyloarthropathies
- 42: Tim Vyse: Genetics of Connective tissue diseases
- 43: Wendy Thomson and Anne Hinks: Genetics of juvenile rheumatic disease
- 44: Alexander Macgregor: Genetics of osteoarthritis
- 45: John McBeth: Genetics of chronic musculoskeletal pain
- Section 6 Tissue in health and disease
- 46: Mike Benjamin: The normal functional anatomy of joints
- 47: Lindsey Hooper: Measuring movement and gait
- 48: Reinhard Voll: Innate vs. acquired immunity
- 49: Pierre Miossec: T Cellular side of acquired immunity (T cells)
- 50: Thomas Dörner: Cellular side of acquired immunity (B cells)
- 51: Chris Buckley: Fibroblasts and mesenchymal cells
- 52: Costantino Pitzalis: Synovial pathology
- 53: Georg Schett: Bone turnover
- 54: Martin Rudwaleit: Enthesitis
- 55: Robert Dinser: Skeletal muscle physiology and damage
- 56: Thomas Pap: Joint biochemistry
- 57: Justin Mason: Vascular biology
- 58: Elena Neumann: Acute phase responses and adipocytokines
- 59: Rainer Straub and Hans-George Schaible: Pain neurophysiology
- 60: Lucy Wedderburn: The pathogenesis of juvenile idiopathic arthritis
- Section 7 Practical investigation of rheumatic disease
- 61: Patrick Kesteven: Haematology
- 62: Patrick Twomey: Biochemical investigation of rheumatic diseases
- 63: Neil McHugh: Auto-immune serology
- 64: Matthew Pickering: Complement
- 65: Mike Benjamin: Limb anatomy and medical imaging
- 66: Andrew Grainger: Radiographic imaging
- 67: Phil Platt: Ultrasound
- 68: Phil O'Connor: Magnetic resonance imaging
- 69: Geoff Hide: Computed tomography
- 70: Adil Al-Nahhas: Nuclear medicine
- 71: Karl Johnson: Imaging in children
- 72: Tony Freemont: Assessment of synovial joint fluid
- 73: Benjamin Schreiber: Cardiopulmonary investigation
- 74: Julian Blake: Electrophysiology
- Section 8 Management of rheumatic disease
- 75: David Walker: Patient education
- 76: Sarah Ryan: Multidisciplinary treatment
- 77: Kay Brune: Cyclooxygenase inhibitors
- 78: Philip Conaghan: Analgesics
- 79: Frank Buttgereit: Glucocorticoids
- 80: Joanna Ledingham: Immunosuppressants
- 81: Roy Fleischmann: Signalling pathway inhibitors
- 82: Andrew Östör: Anti-cytokine biologics
- 83: John Isaacs: Cellular therapies
- 84: Daniel Lovell: Biologics in paediatric rheumatic diseases
- 85: Alan Tyndall: Stem cell therapies
- 86: Andrew McCaskie: Tissue engineering
- 87: Phil Platt: Injection therapy
- 88: Dorothy Pattison: Diet and obesity
- 89: Edzard Ernst: Alternative therapies
- 90: Ian McNab: Principles of upper limb surgery
- 91: Damien Griffin: Principles of lower limb surgery
- 92: Jeremy Fairbank: Principles of spine surgery
- 93: Loreto Carmona: Perioperative management of immunosuppression
- 94: Van Assen: Vaccination in immunocompromised adults
- 95: Nico Wulffraat: Vaccination in immunocompromised children
- 96: Ravelli and Ruperto: Principles of management of juvenile idiopathic arthritis
- 97: Tarnya Marshall: Anti-rheumatic drugs in pregnancy and lactation
- Section 9 Infection in rheumatic disease
- 98: Max Field: Septic arthritis in adults
- 99: Julia Clark: Bone and joint infections in children
- 100: Jeremy Field: Osteomyelitis
- 101: Andreas Krause: Lyme disease
- 102: Stanley J. Naides: Viral arthritis
- 103: Rita Abdulkader: Mycobacterial diseases
- 104: Eliseo Pascual: Brucellar arthritis
- 105: Yusuf Patel: Parasitic involvement
- 106: Richard Watts: Fungal arthritis
- 107: Susan Hopkins: Opportunistic infection
- 108: Andrew C. Steer: Rheumatic fever
- Section 10 Rheumatoid arthritis
- 109: Andy Cope: Pathogenesis of rheumatoid arthritis
- 110: Daniel Aletaha: Rheumatoid arthritis - diagnosis
- 111: Gerd Burmester: Rheumatoid arthritis - clinical features
- 112: Chris Deighton: Rheumatoid arthritis - management
- Section 11 Spondyloarthropathies
- 113: Joachim Sieper: Axial Spondyloarthritis
- 114: Philip Helliwell: Psoriatic arthritis
- 115: J.S. Hill Gaston: Reactive arthritis and enteropathic arthropathy
- Section 12 Arthropathies primarily occuring in childhood
- 116: Eileen Baildam: Juvenile idiopathic arthritis
- Section 13 Systemic lupus erythematosus
- 117: Caroline Gordon: Systemic lupus erythematosus - clinical features and aetiopathogenesis
- 118: David Isenberg: Systemic lupus erythematosus - management
- 119: Michael Beresford: Paediatric onset systemic lupus erythematosus
- 120: Munther A. Khamashta: The antiphospholipid antibody syndrome
- Section 14 Scleroderma
- 121: Chris Denton: Systemic sclerosis
- 122: Francesco Zulian: Paediatric scleroderma and related disorders
- 123: Cate Orteu: Nephrogenic systemic fibrosis
- Section 15 Myositis
- 124: Hector Chinoy: Polymyositis and dermatomyositis in adults
- 125: Clarissa Pilkington: Paediatric polymyositis and dermatomyositis
- 126: Mark Roberts: Non-inflammatory myopathies
- Section 16 Sjögren's syndrome
- 127: Simon Bowman: Sjögren's syndrome: clinical features
- 128: Wan-fai Ng: Sjögren's syndrome: management
- Section 17 Overlap/undifferentiated syndrome
- 129: Ariane Herrick: Overlap/undifferentiated syndrome
- Section 18 Vasculitis
- 130: Richard A.Watts: Classification and diagnosis
- 131: Julia Holle: Clinical features of primary ANCA-associated vasculitis
- 132: David Jayne: Treatment of ANCA vasculitis
- 133: Carlo Salvarani: Large vessel vasculitis
- 134: Charles Raine: Polymyalgia rheumatica
- 135: Hasan Yaziçi: Behcet's syndrome
- 136: Paul Brogan: Paediatric vasculitis
- 137: Richard A. Watts: Miscellaneous vasculitides
- Section 19 Osteoarthritis
- 138: Tonia Vincent: Pathogenesis of osteoarthritis
- 139: Mike Doherty: Clinical features of osteoarthritis
- 140: Phil Conaghan: Osteoarthritis management
- Section 20 Crystal arthropathies
- 141: Nicola Dalbeth: Gout
- 142: Ed Roddy: Calcium pyrophosphate crystal deposition (CPPD)
- Section 21 Diseases of bone and cartilage
- 143: David Reid: Osteoporosis
- 144: Stuart Ralston: Paget's disease of bone
- 145: Nick Bishop: Paediatric metabolic bone disease
- 146: Ashok Bhalla: Disorders of bone mineralisation: Osteomalacia
- 147: Craig Gerrand: Bone Tumours
- 148: Stefan Rehart: Avascular necrosis
- 149: Thomas Bardin: Renal osteodystrophy
- 150: Paul Wordsworth: Skeletal dysplasias
- Section 22 Regional rheumatic disease
- 151: Andrew Ostor: Shoulder
- 152: Karen Walker-Bone: Elbow
- 153: Karen Walker-Bone: Forearm, hand and wrist
- 154: Cathy Speed: Pelvis, groin and thigh
- 155: Roger Wolman: Knee
- 156: Tony Redmond: Foot and ankle
- 157: David Walsh: Cervical and lumbar spine
- 158: Kristin Houghton: Childhood regional conditions
- 159: Alan Hakim: Hypermobility syndromes
- 160: Nick Shenker: Fibromyalgia and chronic widespread pain syndromes: adult onset
- 161: Jacqui Clinch: Fibromyalgia and chronic widespread pain syndromes: adult onset
- 162: Nicola Maffulli: Sports and exercise injuries
- Section 23 Miscellaneous conditions
- 163: Phil Hawkins: Amyloidosis
- 164: Helen Lachmann: Auto-inflammatory diseases
- 165: Cord Sunderkotter: Panniculitides
- 166: Thomas Krieg: Neutrophilic dermatoses
- 167: Joachim Mueller-Quernheim: Sarcoidosis
- 168: Alexei Grom: Macrophage activation syndrome
- 169: Hermann Einsele: Multicentric reticulohistiocytosis
- 170: Bernard Manger: Inherited metabolic diseases
- 171: Gerry Rayman: The rheumatological manifestations of endocrine disorders
- 172: David Rees: Haemoglobinopathies
- 173: Graeme Carroll: Haemochromatosis
