Diabetes and Neurodegeneration

著者名：Bagchi PhD, Debasis (EDT)/Banik PhD, Samudra Prosad (EDT)/Chaurasia, Rameshwar Nath (EDT)

Academic Press（2025/12/03発売）

• 言語：ENG
• ISBN：9780443333552
• eISBN：9780443333569

Description

Diabetes and Neurodegeneration unlocks the complex interplay between diabetes and Neurodegeneration, reviewing the relationship between these two prevalent health challenges. This book begins with a simple guide to understanding high blood sugar, tracing the historical milestones of hyperglycemia, and unveiling the primary factors that contribute to diabetes development, from genetic predisposition to lifestyle hazards. The second section aims to bridge the gap between diabetes and dementia, presenting early clinical evidence, case studies, and susceptibility assessments that underscore the strong link between hyperglycemia and neurodegeneration. Biomarkers and pathways connecting these conditions are explored, including the role of Advanced Glycated End (AGE) products and their implications in protein misfolding and aggregation. The narrative extends to therapeutic strategies, evaluating the efficacy of antidiabetic drugs, targeting insulin resistance, and introducing novel interventions to arrest amyloid-associated pathogenesis. This comprehensive guide provides both clinicians and researchers with a thorough understanding of the intricate link between diabetes and neurodegeneration.- Identifies the cognitive impairment symptoms and the direct impact on the nervous system's structure and electrophysiology- Explores disruptions in insulin signaling as key contributors to neurodegeneration in hyperglycemic individuals- Highlights early diagnostic and prognostic indicators of diabetes and cognitive impairment- Discusses signaling pathways including the insulin signaling pathway and the AGE-RAGE axis that connect diabetes and dementia- Evaluates the efficacy of antidiabetic drugs, targets insulin resistance, and critically assesses RAGE-based therapeutic interventions- Presents novel therapeutics to arrest and delink diabetes from the progression of cognitive impairment

Table of Contents

INTRODUCTION: PATHOGENESIS OF DIABETES AND DEMENTIA1. Why and when does one have high blood sugar?2. The History of hyperglycemia: key milestones in the inception of the disease in human health3. Neurodegeneration: How to identify the primary symptoms of cognitive impairment4. Direct consequences of diabetes over the nervous system: Structural and electrophysiological changesDISCOVERING THE BRIDGE BETWEEN DIABETES AND DEMENTIA5. Early Clinical Evidence that suggest a strong link between Hyperglycemia and onset of neurodegeneration6. Case studies for a systematic understanding of development of dementia in diabetic or pre-diabetic patients7. Susceptibility assessment of dementia in diabetic or prediabetic conditions8. Metabolic connections between Diabetes and AD9. Role of diabetes and altered metabolic homeostasis in age related dementia10. Oxidative stress in brain accelerates the onset of neurodegeneration in hyperglycemic individuals11. Cardiovascular diseases in diabetic individuals aggravate the propensity of dementia12. Disruption of insulin signaling causes major cognitive impairmentBIOMARKERS AND PATHWAYS WHICH CONNECT DIABETES AND DEMENTIA13. Early diagnostic and prognostic biomarkers of diabetes and cognitive impairment14. Periphery biomarkers to assess the vulnerability of Type 2 diabetic patients to AD15. Advanced Glycated End (AGE) Product: the most significant metabolic by-product implicated in dementia16. The Physiological role of AGE: RAGE axis in the body: Implications in cellular defense17. Role of AGE molecules in protein misfolding and aggregation18. AGE molecules as major culprits behind amyloidogenic protein aggregation19. Shared pathways of Type 2 diabetes and Alzheimer's Disease20. Role of gut microbial amyloids in progressive cognitive decline21. Exploring the unknown territory of Gut: Brain axis in diabetic patients: impact of elevated blood sugar on microbial amyloidsTHERAPEUTIC STRATEGIES TO ARREST AND/OR DELINK DIABETES AND DEMENTIA22. Evaluation of efficacy of antidiabetic drugs to arrest dementia23. Targeting Insulin resistance to treat cognitive impairment24. RAGE based therapeutic interventions: Do they aggravate or ameliorate dementia?25. Soluble form of RAGE (sRAGE) receptors as novel therapeutic intervention to arrest amyloid associated pathogenesis26. Assessing the efficacy of antidiabetic phytotherapeutic interventions towards improvement of cognitive functionsFUTURE FRONTIERS IN DIABETES AND DEMENTIA27. Commentary: Diabetes and cognitive health: How can we save the future generation