Description
Recent Advances in Hemodynamics and Blood Mimetics is a comprehensive compilation of recent developments in biofluid mechanics and biomimetics, covering topics such as numerical modeling, biomedical applications of microfluidics, biomimetic flows, biomedicine applications, and organ-on-chip technology. The book explores blood hemodynamics at different scales, including application to diseases, the relationship between blood biomechanics and rheology, the mimetization of blood properties at arterial and capillary level, including the study of blood mechanical and flow properties, flow and surface properties of blood cells, and mimetization of these same properties in fluid/particle systems.These concepts are applied to the development of organ-on-chip to improve the replication of biological processes in the human body. The book organizes recent knowledge on hemodynamics and blood mimetics and is representative of the different lines of research in the field, showing an integrated view of blood biomechanics encompassing all scales to create a valuable resource where different research lines can be found and their principles understood.- Presents comprehensive and up-to-date coverage of the latest research and developments in the field of hemodynamics and biomimetics- Features contributions from leading researchers and experts in the field who bring together expertise from different disciplines and provide a broad overview of major themes and challenges in the field- Provides an integrated view of the field, from the microscale to macroscale, from fundamentals to applications- Combines theory, numerical, and experimental approaches
Table of Contents
Section 1. Numerical methods1. Patient specific hemodynamics2. Two-phase flows (VOF method, Euler-euler methods, Euler-Lagrange methods)3. Macroscopic rheological properties estimated from microstructure of particle suspension4. Dissipative Coupling of Fluid and Immersed Objects for Modelling of Cells in Flow5. Flow of blood cells in microfluidic channels: a dissipative particle dynamics simulation studySection 2. Biomedical applications of microfluidics6. Biomechanics of blood cells7. Techniques to fabricate microparticles for hemodynamic applications8. Hemodynamics in the Microcirculation and in Microfluidics9. Applications of inertial microfluidics in biomedical research10. Properties and applications of PDMS microfluidic devices11. In vitro hemodynamicsSection 3. Biomimetics and bioinspired flows12. Review on blood analogue fluids13. Murray's Law in blood vessel networks14. Mechanical behavior of bio-inspired systems15. Flow in microfluidic systems using networks of bio-inspired soft valves16. Biomimetics of the pulmonary environment in vitroSection 4. Applications to biomedicine17. Gas embolisms in small vessels - formation, vessel clogging, flow18. Pathological Hemodynamics19. Flow Visualizations in PDMS Cerebral Aneurysm Biomodel20. Blood flow in a cerebral aneurysm21. Mechanical characterization of pathological bloodSection 5. Micro and nano flow applications in organ on chips22. PDMS surface modification for microfluidic devices and organ on chip platforms23. Flow assessment and analysis of oxygen transport in an organ on chip platform24. Micro/Nanomachines for biomedical applications25. Effects of microneedle design parameters on hydraulic resistance26. PDMS Microneedles for organ-on-chip platforms
