眼の薬剤送達：発展、産業化の可能性、応用 Ophthalmic Drug Delivery : Advancement, Industrialization Prospect and Applications

著者名：Mehra PhD, Neelesh Kumar (EDT)

Academic Press（2025/08/01発売）

• 言語：ENG
• ISBN：9780443337819
• eISBN：9780443337826

Description

Ophthalmic Drug Delivery: Advancement, Industrialization Prospect and Applications delves into the complexities and potential of scaling up and commercializing pharmaceutical innovations within ophthalmology. This book serves as a complete guide through research findings, industry insights, and regulatory guidelines, offering a thorough roadmap for the future of drug delivery systems targeting the eye. The importance of understanding the eye's physiology and anatomy is emphasized, laying the foundational knowledge necessary for developing effective treatments. The book continues by exploring various aspects such as novel formulations, fixed-dose combinations, and microbiological considerations.It also discusses cutting-edge research in reverse engineering approaches, the significance of Quality by Design (QbD), and the treatment of eye-related diseases like glaucoma, age-related macular degeneration, uveal melanoma, cataracts, and fungal keratitis. Corporate researchers will find the manufacturing insights particularly beneficial, making this an essential resource for professionals in the field of ophthalmic drug delivery.- Combines fundamental concepts, theory, and cases of formulations to manage of eye-related diseases- Focuses on recent advances in drug delivery to the eye- Provides an overview of the regulatory framework around ophthalmic dosage forms

Table of Contents

1. Introduction to Ocular Drug Delivery: Core Principles and Fundamental Concepts2. Complex ophthalmic Drug delivery Approaches3. Excipients and polymers in complex ophthalmic products: Formulation science and engineering perspectives4. Fixed-Dose Combination technique in ophthalmic products5. Emerging trends in ophthalmic products: Microneedles, hydrogels, and ocular inserts6. Reverse Engineering strategy in Complex Ophthalmic Product7. Quality by design and Design of Experiments (DOE) in Ophthalmic Product Development: Statistical Approaches and Optimization Strategies8. Translational roadmap for complex ophthalmic products9. Manufacturing Consideration, Scale-Up and Validation in Sterile Ophthalmic Formulation10. Safety Assessment and Toxicological Considerations of Nanocarriers in Ophthalmic Drug Delivery: Risk management, Animal Model and Preclinical Evaluation11. Advanced packaging, container and closure system for complex ophthalmic products12. Role of 3D Printing in Ophthalmic Products13. Stability Studies of Ophthalmic Product14. Regulatory Landscape of Ophthalmic Products