Description
Hyponatremia and 40 Years of Controversy: Looking Back and Moving Forward traces and probes the prolonged, contentious debate surrounding the treatment of severe hyponatremia, a low-sodium concentration in the blood that can result in severe brain damage if managed incorrectly.A mix of memoir and science, the book explains how slow correction of hyponatremia became accepted and how consensus was disrupted by assertions that caution was unnecessary and harmful. It scrutinizes the controversy, offers an approach to management, and unpacks research limitations – reminding us that what is believed true today may change tomorrow.Hyponatremia and 40 Years of Controversy: Looking Back and Moving Forward is a vital resource for both experienced medical specialists and novice trainees. It explains the physiology of how hyponatremia happens and how it hurts. By offering historical insights, scientific rigor, and practical guidance, this book promises to enhance clinical decision making, foster new research, and improve outcomes in patients with hyponatremia.- Offers detailed yet accessible scientific explanations, making complex medical concepts understandable to nonscientific readers- Explores in-depth historical background covering the factors that have influenced and sustained the controversy, allowing readers to understand why disagreements persist.- Contains a practical toolbox with helpful tips on how to successfully manage hyponatremia
Table of Contents
PART ONE: Salt, Science, Serendipity, and Strife 1. From central pontine myelinolysis (CPM) to osmotic demyelination syndrome (ODS)2. What's rapid correction?3. Osmotic stress and demyelination4. Hyponatremic Encephalopathy: Age, Sex, Hormones and Oxygen5. Speed Limits and How to Obey ThemPART TWO: Climbing the ladder and finding the ground6. New Evidence: Rare or just not well done?7. The Court's in Session8. Primum non nocere9. Beyond osmosis: malnutrition, alcoholism, and the liver10. A toolbox for managing hyponatremia
