Description
Nanotheranostics and Precision Oncology delves into the merging fields of cancer research and nanotechnology, offering a thorough review of the latest advancements in precision oncology. It begins with an exploration of cancer biology, illuminating the genetic foundations of oncogenesis alongside the cellular and molecular mechanisms driving cancer progression, metastasis, and drug resistance. This resistance remains the foremost challenge in cancer care. Across 28 chapters, the book addresses precision medicine's role in overcoming drug resistance, the importance of biomarkers, the interpretation of genetic analyses, and the shift toward personalized oncology.In addition, the book examines nanotheranostics' applications and mechanisms in cancer diagnosis and treatment, integrating them with precision oncology. It outlines the design, mechanism, and impact of nanoprecision medicine in cancer management. The final section considers the future of nanotheranostics in precision oncology and the challenges of translating these innovations from research to clinical practice. This comprehensive guide serves students, clinicians, researchers, and the pharmaceutical industry involved in nanomedicine, oncology, molecular biology, and precision medicine.- Offers a comprehensive look at cancer biology and the genetic roots of oncogenesis- Provides in-depth coverage of the latest in precision oncology and nanotheranostics, including development and clinical use- Explores the integration of nanotechnology with precision medicine for creating individualized treatments- Includes case studies and regulatory insights that guide pharmaceutical innovation and clinical practice
Table of Contents
Section I: Cancer biology1. Oncogenesis: Genetic basisAnum Chaudhry, Hania Shah and Shan e Zahra Sheikh2. Hallmarks of cancerFizzah Abid and Mudassir Khan3. Cancer stem cells and tumor microenvironmentAsma Areesh and Rimsha Sahr4. Mechanisms underpinning invasion and metastasisSuhail Razak, Sameen Zafar and Tayyaba Afsar5. Drug resistance in cancerZarish Fatima, Tayaba Irfan, Maria Shabbir and Yasmin BadshahSection II: Precision oncology6. Introduction to precision medicineMaryam Akmal and Iqra Mutiullah7. Translational bioinformatics and precision medicineMaaz Waseem8. Proteomics, metabolomics, and precision medicineFizzah Abid and Ghulam Murtaza Kamal9. Biomarkers and circulating DNAs as predictive molecular signaturesMomina Tariq and Amaara Niazi10. Genomic strategies for precision medicineAsma Latif, Farheen Zahid and Yasmin Badshah11. Immunotherapy as a tool of precision medicineHaipeng Tao, Rameesha Fareed, Robert Dalton, Richa Gupta, Anjali Chauhan, Ravi Kumar, Srabasti Sengupta, Chong Zhao, Meiqi Shi and Muhammad Abbas12. Clinically approved and under trial drugs for precision oncologySyeda Tahira Qousain Naqvi and Sana KhalidSection III: Nanotheranostics13. Introduction to nanotheranosticsMaisra Azhar Butt and Sobia Tabassum14. Active and passive targeting of nanoparticlesMaisra Azhar Butt and Sobia Tabassum15. Nanocontrasts, nanoprobes, and nanosensors in cancer diagnosisMushkbar Fatima, Laleen Saeed and Ramish Riaz16. Nanoparticles as delivery vehicle for drugs and genesAleena Haqqi and Zeemal Seemab Amin17. Nanoparticles for thermal ablationUsama Masood, Tayyaba Hussain and Madeeha ChaudhrySection IV: Designing nanotheranostics for precision medicine18. Current status of nanotheranostics in precision medicineMuhammad Abu Bakar Saddique, Muhammad Dawood Amjad, Huzaifa Tahir and Khired Sajid19. Nano-immunotherapyAneela Mustafa and Amna Hafeez20. Stimuli-responsive nanotheranostics for precision medicineSehrish Abbas and Bushra Uzair21. Pharmacogenomics-based nanoprecision medicineSidrah Hafeez and Shafia Maryam22. ADME of nanoprecision medicines: Understanding the pharmacokinetics and pharmacodynamics of nanoprecision medicinesKaynat Iftekhar, Khired Sajid, Maria Rafiq and Mudassir KhanSection V: Challenges and future potentials23. Challenges in translation of nanoprecision medicineRimsha Ashraf, Tauqeer Hussain, Muhammad Summer and Shaukat Ali24. Ethical and legal considerations in the use of nanotheranostics and precision medicineAmna Naheed Khan and Erum Dilshad25. Economic challenges in use of nanotheranostics and precision medicineAreeba Ikram, Asma Rehman and Ramish Riaz26. Biomarkers emerging in nanotheranostics and precision medicineTooba Khan, Zainab Nisar Qureshi, Amaara Niazi, Mahnoor Ejaz and Khushbukhat Khan27. Panomics, artificial intelligence, and precision medicineMahnoor Basit, Momna Jamil, Rohma Jamil, Muhammad Haroon and Khushbukhat Khan28. Nanotheranostics and precision medicine redefining the future of healthcareRoomisa Anis, Muhammad Huzaifah Qureshi, Fatima Irfan and Seyyedha Abbas
