Description
**Selected for 2025 Doody's Core Titles® in Infectious Disease**Offering more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than any other infectious disease resource, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 10th Edition, remains your #1 choice for authoritative, comprehensive information in this challenging field. Meticulously updated by a new editorial team led by Drs. Martin J. Blaser, Jeffrey I. Cohen, and Steven M. Holland, this two-volume masterwork brings together the knowledge and expertise of more than 650 contributing authors who are outstanding scholars and experts in their fields. For ID specialists and general practitioners alike, PPID provides a balanced, detailed perspective for any patient you encounter with a complex or difficult-to-treat infectious disease. Encyclopedic in its depth, contents, and referencing, PPID-10 is the one infectious disease book that needs to be on every practitioner's shelf and in every medical library.- Organizes content both by individual pathogens and by important clinical syndromes, broadening the context to clearly present relevant, complex clinical information.- Contains multiple new chapters on both SARS-CoV-2 and anti-fungal therapy, as well as new chapters on bacteriophages and related agents, infections following traumatic injuries, communication to the public about infectious diseases, and the effects of climate change on infectious diseases.- Provides up-to-date coverage of recent advances in the field: an increasing understanding of the agents, immune responses, and the growing armamentarium of diagnostics (such as nucleic acid amplification and next-generation sequencing); new treatments (such as monoclonal antibodies, new antifungals, antivirals, and phage therapy); and emerging preventive measures (such as new vaccines being developed for RSV), and our relationship with the human microbiome.- Features more than 1,500 high-quality, full-color photographs―with many new to this edition.- Shares the extensive experience of new editors Drs. Jeffrey I. Cohen and Steven M. Holland, both from Bethesda, MD, as well as a new team of expert associate editors Drs. Yohei Doi, Wendy S. Garrett, Ann R. Falsey, Eleanor Wilson, Kieren Marr, and Edward Mitre—each a leading authority in their field.- Includes perspectives from hundreds of leading experts from a truly global community, including authors from Australia, Canada, and countries in Europe, Asia, and South America.- Includes regular updates online for the life of the edition.- Any additional digital ancillary content may publish up to 6 weeks following the publication date.
Table of Contents
I Basic Principles in the Diagnosis and Management of Infectious DiseasesA Microbial Pathogenesis1 A Molecular Perspective of Microbial Pathogenicity2 The Human Microbiome3 Prebiotics, Probiotics, and SynbioticsB Host Defense Mechanisms4 Innate (General or Nonspecific) Host Defense Mechanisms5 Adaptive Immunity: Antibodies and Immunodeficiencies6 Cell-Mediated Defense Against Infection7 Mucosal Immunity8 Granulocytic Phagocytes9 Complement and Deficiencies10 Human Genetics and Infection11 Nutrition, Immunity, and Infection12 Evaluation of the Patient With Suspected ImmunodeficiencyC Epidemiology of Infectious Disease13 Principles of Applied Epidemiology for the Practice of Infectious Diseases14 Emerging and Reemerging Infectious Disease Threats15 Bioterrorism: An OverviewD Clinical Microbiology16 The Clinician and the Microbiology Laboratory: Test Ordering, Specimen Collection, and Result InterpretationE Anti-infective Therapy17 Principles of Anti-infective Therapy18 Molecular Mechanisms of Antibiotic Resistance in Bacteria19 Pharmacokinetics and Pharmacodynamics of Anti-infective Agents20 Penicillins and β-Lactamase Inhibitors21 Cephalosporins and Cephalosporin/ β-Lactamase Inhibitor Combinations22 Carbapenems, Carbapenem/ β-Lactamase Inhibitor Combinations, and Aztreonam23 Antibiotic Allergy24 Aminoglycosides25 Tetracyclines, Tetracycline Derivatives, and Chloramphenicol26 Rifamycins27 Metronidazole28 Macrolides and Clindamycin29 Glycopeptides (Vancomycin and Teicoplanin) and Lipoglycopeptides (Telavancin, Oritavancin, and Dalbavancin)30 Streptogramins (Quinupristin-Dalfopristin) and Lipopeptides (Daptomycin)31 Polymyxins (Polymyxin B and Colistin)32 Linezolid, Tedizolid, and Other Oxazolidinones33 Sulfonamides and Trimethoprim; Trimethoprim-Sulfamethoxazole34 Quinolones35 Antibiotics in Advanced Development and Other Agents36 Urinary Tract Agents: Nitrofurantoin, Fosfomycin, and Methenamine37 Topical Antibacterials38 Antimycobacterial Agents39 Bacteriophage Therapy, Endolysin Therapy, and Antimicrobial Peptide Therapy40 Antifungal Agents: Polyene Antifungals41 Antifungal Drugs: Azole42 Antifungal Drugs: Echinocandins and Other Beta-d-Glucan Inhibitors43 Antifungal Drugs: Flucytosine44 Antimalarial Drugs45 Drugs for Protozoal Infections Other Than Malaria46 Drugs for Helminths47 Antiviral Agents: General Principles48 Antiviral Drugs for Influenza and Other Respiratory Virus Infections Except for SARS-CoV-249 Antivirals Against Herpesviruses50 Antiviral Drugs Against Hepatitis Viruses51 Miscellaneous Antiviral Agents (Interferons, Tecovirimat, Imiquimod, Pocapavir)52 Immunomodulators53 Hyperbaric Oxygen54 Antibiotic Stewardship55 Designing and Interpreting Clinical Studies in Infectious Diseases56 Outpatient Parenteral Antimicrobial TherapyII Major Clinical SyndromesA Fever57 Temperature Regulation and the Pathogenesis of Fever58 Fever of Unknown Origin59 The Acutely Ill Patient With Fever and RashB Upper Respiratory Tract Infections60 The Common Cold61 Pharyngitis62 Acute Laryngitis63 Otitis Externa, Otitis Media, and Mastoiditis64 Sinusitis65 Epiglottitis66 Infections of the Oral Cavity, Neck, and HeadC Pleuropulmonary and Bronchial Infections67 Acute Bronchitis68 Acute Exacerbations of Chronic Obstructive Pulmonary Disease69 Acute Pneumonia70 Pleural Effusion and Empyema71 Bacterial Lung Abscess72 Chronic Pneumonia73 Cystic FibrosisD Urinary Tract Infections74 Urinary Tract InfectionsE Sepsis75 Sepsis and Septic ShockF Intraabdominal Infections76 Peritonitis and Intraperitoneal Abscesses77 Infections of the Liver and Biliary System (Liver Abscess, Cholangitis, Cholecystitis)78 Pancreatic Infection79 Splenic Abscess80 Appendicitis81 Diverticulitis and Neutropenic EnterocolitisG Cardiovascular Infections82 Endocarditis and Intravascular Infections83 Prosthetic Valve Endocarditis84 Infections of Nonvalvular Cardiovascular Devices85 Prevention of Infective Endocarditis86 Myocarditis and Pericarditis87 MediastinitisH Central
