Cell-based Immunotherapies for Cancer

著者名：Mishra, Alok K. (EDT)/Malonia, Sunil K. (EDT)

Springer（2025/06/24発売）

• 言語：ENG
• ISBN：9783031886942
• eISBN：9783031886959

Description

This book explores the rapidly evolving field of cancer immunotherapy, which focuses on harnessing the immune system's power to combat cancer. As traditional treatments like chemotherapy and radiation therapy often have significant side effects and may not be effective for all cancer types, immunotherapy offers a promising alternative.

Among the most notable advancements in this field are cell-based therapies, which involve modifying a patient’s own immune cells or engineering specialized cells to enhance their ability to target cancer. Key approaches include chimeric antigen receptor (CAR) T-cell therapy, tumor-infiltrating lymphocyte (TIL) therapy, and dendritic cell (DC)-based therapy.

Providing a comprehensive overview of these therapies, this book explores their scientific foundations, recent developments, clinical applications, and associated challenges. It also discusses emerging immunotherapeutic strategies, the commercial landscape, and future research directions.

A valuable resource for researchers, clinicians, and industry professionals involved in cancer treatment, this book also serves as an informative reference for students and academics in biology, biotechnology, immunology, and related disciplines seeking a deeper understanding of cancer immunotherapy.

Table of Contents

Chapter 1. Cellular Immune Responses in Tumor Microenvironment.- Chapter 2. The Evolution of Cancer Immunotherapy: A Journey from Concept to Clinical Reality.-  Chapter 3. Tumor Infiltrating Lymphocytes: ACTing against Solid Tumors.- Chapter 4. CAR-T Cells: Design Principles, Core Concepts, and Clinical Applications.- Chapter 5. CAR-T Cell Therapies for Hematological Malignancies.- Chapter 6. CAR-T Cell Therapies for Solid Tumors.- Chapter 7. The Next-Generation CAR-T cell Therapies.- Chapter 8. CAR-T cell Therapies Associated Toxicities.- Chapter 9. T-cell Receptor Engineered T (TCR-T) Cell Therapy.- Chapter 10. Unconventional T Cells: Biology, Functions and Their Implications in Cancer.- Chapter 11. Adoptive Cell Therapies Using Unconventional T Lymphocytes.- Chapter 12. The emerging role of CAR-NK cells: Next-generation cancer immunotherapy.- Chapter 13. Dendritic Cell-Based Therapies.- Chapter 14. Allogeneic Cells for Cellular Immunotherapy.- Chapter 15. CAR Macrophages for Solid Tumors.