Description
Parkinson's disease becomes apparent only after substantial loss (60%) of the dopamine neurons in the substantia nigra. By this time there has already been widespread neural inclusion formation in the peripheral and central nervous system of patients with the disease, although this has only been recognized more recently. Degeneration in these widespread regions of the peripheral and central nervous system is now known to impact on disease symptoms, progression and treatment over time. This book aims to provide a comprehensive review of these non-dopamine lesions in Parkinson's disease by assessing our current knowledge of their presence and pathophysiology, how they relate to different symptoms and, where relevant, discuss how they may be potentially treated. The book addresses most of the known symptoms that occur in patients with Parkinson's disease. In addition to the classic motor triad, motor speech, eye movements, olfactory dysfunction, autonomic dysfunction, pain and sensory abnormalities, sleep disturbances, depression and apathy, dopamine dysregulation syndromes, hallucinations and psychoses, cognitive impairment and dementia, and systemic manifestations are all reviewed. Early selective cell loss in non-dopaminergic regions is highlighted (the glutamate projection neurons of the presupplementary motor cortex and caudal intralaminar thalamus) in addition to the widespread inclusion formation in many regions outside the basal ganglia that characterize the disease. Overall this book provides a comprehensive analysis of the lesions associated with the most common symptoms found in patients with Parkinson's disease.
Table of Contents
TABLE OF CONTENTSContributorsChapter 1: Lesions Associated with the Classic Triad of Parkinsonian Motor Features Stanley Fahn and Glenda M. HallidayChapter 2: Lesions Associated with Motor Speech Anna Rita Bentivoglio, Davide Quaranta, and Aileen K. HoChapter 3: Lesions Associated with Eye MovementsAndrew W. Michell, Roger A. Barker, and Glenda M. HallidayChapter 4: Olfactory Dysfunction in Parkinson's Disease and Related Disorders Richard L. Doty, Christopher Hawkes, and Henk W. BerendseChapter 5: Lesions Associated with Autonomic Dysfunction A: Swallowing Disorders and Drooling Maria G. Cersosimo and Eduardo E. Bennarroch B: Gastrointestinal Disorders Adolfo Mínguez-Castellanos and Dominic B. Rowe C: Orthostatic Hypotension Spiridon Papapetropoulos and Kathryn K. PostChapter 6: Lesions Associated with Pain and Sensory Abnormalities Andreas Hartmann and Glenda M. HallidayChapter 7: Lesions Associated with Sleep DisturbancesMarcus M. Unger, Wolfgang H. Oertel, Thomas C. Thannickal, Yuan-Yang Lai, and Jerome M. SiegelChapter 8: Lesions Associated with Depression and Apathy Uwe Ehrt, Kenn F. Pedersen, and Dag AarslandChapter 9: Lesions Associated with Dyskinesias and the Dopamine Dysregulation Syndrome Andrew H. EvansChapter 10: Lesions Associated with Visual Hallucinations and Psychoses David R. Williams and Werner PoeweChapter 11: Lesions Associated with Cognitive Impairment and Dementia Jonathan Evans, Tamas Revesz, and Roger A. BarkerChapter 12: Systemic Manifestations of Parkinson's DiseaseDominic B. RoweIndex
