Description
Migraine Management: Current Pharmacological and Non-pharmacological Options is a comprehensive guide to established, recent, and ongoing pharmaceuticals and device development projects. The book provides detailed information on the historical developments of migraine pain management, druggable targets, drugs action mechanisms, drugs for acute treatment and preventive care of patients, administration routes, and alternative treatments. This is the ideal reference for academic researchers interested in anti-migraine pharmacology. It will also be a perfect reference for physicians and care professionals involved in the well-being of migraine patients.- Offers a comprehensive overview of pharmacological and alternative migraine pain treatment options- Covers the historical developments and current targets for drug development and delivery routes- Provides insights into comorbidities and their impact in patient compliance to treatment
Table of Contents
Part I: Foundations and historical development of migraine pain management 1. Introduction2. Neuroanatomy and Neurophysiology3. Historical overview of migraine product development 4. Comorbidities and their impact on therapies 5. Not all Migraine attacks are the same 6. Challenges and Controversies; Pharmacokinetics, Linguistics, Semantics and Statistics Part II: Druggable targets7. CGRP8. PACAP 9. Src family kinases (SFK) in Migraine10. Delta opioid receptor system 11. Piezo channels in peripheral trigeminal nociception 12. TRP antagonists Part III: Drugs – Acute Management13. Simple analgesics and combination oral products14. Cannabinoids & Phytochemicals15. Ergots 16. Triptans 17. Beta blocker (timolol) eye drops 18. Lasmiditan (and the ditan class) 19. Gepants Part IV: Drugs – Prevention20. TCAs (Tricyclic Antidepresants), SNRIs, Beta blockers, candesartan, flunarizine21. Antiseizure orals (gabapentin, topiramate)22. Onabotulinumtoxin 23. Gepants (for prevention)24. (CGRP) Monocloncal antibodies Part V: Administration routes25. Oral Drugs (including SMEDDS) 26. Inhaled - oral & nasal27. Subcutaneous/IM/Transcutaneous ("Injectables") 28. IV/Infusion Part VI: Alternative Management29. The role of digital platforms and smartphone apps30. Herbal Medicines31. Phototherapy 32. Neuromodulation 33. Acupuncture (for episodic and chronic migraine)34. Manual Therapies 35. Nutraceuticals and Diets 36. Mindfulness Part VII: Summary & conclusion [Shrewsbury]37. Final Perspectives: oral/non-oral pharmaceuticals; devices; Complimentary practices
