Description
Neuroscience Research in Short-duration Human Spaceflight encapsulates a groundbreaking neuroscience portfolio conducted during the Axiom Mission 2 in May 2023, offering an examination of the effects of short-duration orbital spaceflight on aspects of the human brain. Addressing limitations in existing literature, the research includes astronauts of diverse ages, genders, and ethnic backgrounds, broadening the understanding of the impact of spaceflight on human physiology. A significant aspect of the suite of studies is the validation of two novel devices providing unprecedented information about the pupillary light reflex and neuroimaging in microgravity: automated pupillometry and functional near-infrared spectroscopy. The portfolio extends to explore spaceflight-associated neuro-ocular syndrome, offering valuable contributions to the evolving field of space medicine. Furthermore, the research delves into the utilization of electroencephalography to monitor brain activity, acknowledging its potential in assessing cognitive health, stress levels, and mental workload in real time. Despite promising prospects, challenges in electroencephalography system adaptability within the International Space Station environment are highlighted, emphasizing the need for specialized design considerations. In addition, analysis is extended into the molecular biomarkers through minimally invasive blood monitoring. This book represents a pivotal advancement in space neuroscience, laying the foundation for safer space travel and fostering the development of monitoring tools crucial to observing adverse changes and potentially developing countermeasures that can aid in the establishment of a permanent human presence beyond Earth.- Offers in-depth coverage of the effects of spaceflight on human physiology and the brain- Includes novel data from astronauts on the Axiom Mission 2- Includes a range of monitoring tools to assess neurological activity during and after spaceflight
Table of Contents
1. Unlocking the neurological mysteries of space from Saudi Arabia's inaugural human spaceflight mission (Axiom Mission 2): pioneering insights, novel tools, and pathways to safer future space explorationBader H. Shirah, Christopher E. Mason, Eliah G. Overbey, JangKeun Kim, Shawna Pandya, Yvette Gonzalez, Aaron H. Persad, Mohammed M. Ahmed, Mishaal N. Ashemimry, Muhammad Imran Naseer and Jon Sen2. Automated pupillometry in short-duration human spaceflightBader H. Shirah, Yasser Aladdin, Christopher Mason, Shawna Pandya, Yvette Gonzalez, Aaron H. Persad, Andrew G. Lee, Mohammed M. Ahmed, Mishaal N. Ashemimry and Jon Sen3. Optic nerve sheath ultrasound in short-duration human spaceflightBader H. Shirah, Andrew G. Lee, Christopher Mason, Shawna Pandya, Yvette Gonzalez, Aaron H. Persad, Mohammed M. Ahmed, Mishaal N. Ashemimry and Jon Sen4. Wireless portable electroencephalography in short-duration human spaceflightBader H. Shirah, Sandra Pusil, Fernando Maestu, Patrique Fiedler, Jon Sen, Yasser Aladdin, Christopher Mason, Shawna Pandya, Yvette Gonzalez, Aaron H. Persad, Mohammed M. Ahmed, Mishaal N. Ashemimry, Ana M. Cebolla Alvarez, Guy Cheron and Michael Funke5. Functional Near-Infrared Spectroscopy as a noninvasive neuroimaging technique to measure cerebral perfusion in microgravityBader H. Shirah, Peter Zu Eulenburg, Christopher Mason, Shawna Pandya, Yvette Gonzalez, Aaron H. Persad, Mohammed M. Ahmed, Mishaal N. Ashemimry, Matthias Ertl and Jon Sen6. Surrogate assessment of brain health using longitudinal measures of blood-based biomarkers in short-duration human spaceflightBader H. Shirah, Peter zu Eulenburg, Eliah G. Overbey, JangKeun Kim, Marissa Burke, Jeremy Wain Hirschberg, Isabell Schulze, Krista Ryon, Jacqueline Proszynski, Cem Meydan, Deena Najjar, Jonathan Foox, Paul Collier, Theodore M. Nelson, Dennis J. Zhang, Nosakhare M. Iyoha, Chloe J. Jones, Brianna Przywozny, Thomas Sibilly, Shawna Pandya, Yvette Gonzalez, Aaron H. Persad, Mohammed M. Ahmed, Hatim Bukhari, Muhammad Imran Naseer, Jon Sen, Remi Klotz, Min Yu, Mishaal N. Ashemimry, Jedd Wolchok, Taha Merghoub and Christopher E. Mason7. Telomere length dynamics associated with short-duration human spaceflight 125Bader H. Shirah, Eliah G. Overbey, Jonathan Foox, Jeremy Wain Hirschberg, JangKeun Kim, Krista Ryon, Jacqueline Proszynski, Cem Meydan, Deena Najjar, Paul Collier, Erik LeRoy, Shawna Pandya, Yvette Gonzalez, Aaron H. Persad, Mohammed M. Ahmed, Hatim Bukhari, Muhammad Imran Naseer, Mishaal N. Ashemimry, Lynn Taylor, Taghreed M. Al-Turki, Remi Klotz, Min Yu, Jon Sen, Susan M. Bailey and Christopher Mason8. Evaluation of astronaut experience, future directions, and recommendations for neuroscience research methods in human spaceflightBader H. Shirah, Christopher Mason, Shawna Pandya, Yvette Gonzalez, Aaron H. Persad, Mohammed M. Ahmed, Mishaal N Ashemimry and Jon Sen
