Description
Therapeutic Drug Monitoring 2nd Edition is an updated reference on TDM analytical techniques in diverse clinical settings.This new edition reviews the exciting new developments in the area, including seven new chapters covering immunoassay design and applications, combined chromatographic techniques in therapeutic monitoring, drug monitoring in alternative specimens, pharmacogenomics of anticancer drugs, pharmacogenomics testing for patient management, selected antifungal agents, pharmacodynamic monitoring, and therapeutic drug monitoring of selected anticoagulants. All remaining chapters in the first edition were thoroughly revised and updated.Therapeutic Drug Monitoring 2nd Edition is the ideal reference for clinical pathologists, pharmacologists, and toxicologists involved with TDM. Scientists working in diagnostic companies, developing reagents for monitoring therapeutic drugs will also find relevant information in this book.- Includes new chapters covering antifungal, anticoagulant, and anticancer drugs monitoring- Discusses limitations of current immunoassays, new and sophisticated chromatographic techniques, the clinical effectiveness of newer antiretroviral agents, anticonvulsants and antidepressants- Provides full coverage of pharmacogenomics and personalized medicine, principles of pharmacokinetics and pharmacodynamics, and the application of biomarkers in TDM
Table of Contents
Contents Contributors Preface 1. Introduction to therapeutic drug monitoring: Frequently and less frequently monitored drugs Amitava Dasgupta 1. Introduction 2. Drugs that require therapeutic drug monitoring 3. Benefits of therapeutic drug monitoring 4. Pathophysiological conditions and other factors that affect drug concentrations 5. Therapeutic drug monitoring of various drug class 6. Conclusions References 2. Effects of preanalytical variables in therapeutic drug monitoring Janetta Bryksin and Heather Stieglitz 1. Introduction 2. Lab-related variables 3. Patient-specific variables 4. Conclusions References Further reading 3. Analytical techniques used in therapeutic drug monitoring Michael C. Milone 1. Introduction 2. A general classification of analytical methods 3. Understanding and minimizing measurement uncertainty in the clinical laboratory 4. Immunoassays 5. Gas and liquid chromatography 6. Mass spectrometry and LC-MS/MS application to TDM 7. Conclusions References 4. Therapeutic drug monitoring using alternative specimens: Saliva and dried blood spot Kenichi Tamama 1. Introduction 2. Free drug hypothesis 3. Remote sampling for TDM 4. Oral fluid (saliva) 5. Saliva for TDM 6. Saliva collection 7. Factors affecting the distribution of the analytes in DBS 8. DBS with the precise volume deposition 9. Dried plasma spot 10. DBS for TDM 11. Specimen collection for DBS (and VAMS) 12. Laboratory analysis of saliva and dried blood spot 13. Conclusions References 5. Clinical utility of free-drug monitoring Florin Marcel Musteata 1. Introduction 2. Free concentrations versus total concentrations 3. Applications and methods for monitoring free drug concentrations 4. Alternative methods 5. Conclusions References 6. Therapeutic drug monitoring of classical and newer anticonvulsants Matthew Luke 1. Introduction 2. Pathophysiology of epilepsy 3. Antiepileptic drug monitoring 4. Indications for measuring a drug level 5. Therapeutic drug monitoring of classical AEDs 6. Newer anticonvulsants 7. Therapeutic monitoring of brivaracetam 8. Therapeutic monitoring of cannabidiol 9. Therapeutic monitoring of cenobamate 10. Therapeutic monitoring of clobazam 11. Therapeutic drug monitoring of eslicarbazepine acetate 12. Therapeutic drug monitoring of felbamate 13. Monitoring of fenfluramine 14. Monitoring of gabapentin 15. Therapeutic drug monitoring of lacosamide 16. Therapeutic drug monitoring of lamotrigine 17. Therapeutic drug monitoring of levetiracetam 18. Therapeutic drug monitoring of oxcarbazepine 19. Therapeutic drug monitoring of perampanel 20. Therapeutic drug monitoring of pregabalin 21. Therapeutic drug monitoring of rufinamide 22. Therapeutic drug monitoring of stiripentol 23. Therapeutic drug monitoring of tiagabine 24. Therapeutic drug monitoring of topiramate 25. Therapeutic drug monitoring of vigabatrin 26. Therapeutic drug monitoring of zonisamide 27. Analytical methods for monitoring of AEDs 28. Conclusion References 7. Challenges in therapeutic drug monitoring of digoxin and other antiarrhythmic drugs Amitava Dasgupta 1. Introduction 2. Challenges in therapeutic drug monitoring of digoxin 3. Therapeutic drug monitoring of other antiarrhythmic drugs 4. Chromatographic methods for determining multiple antiarrhythmic drugs simultaneously 5. Conclusions References 8. Guidelines for monitoring vancomycin, aminoglycosides, and other antibiotics Amy L. Pyle-Eilola 1. Introduction 2. Vancomycin 3. Aminoglycosides 4. Therapeutic drug monitoring of beta-lactam antibiotics 5. Therapeutic drug monitoring sulfonamides and trimethoprim 6. Therapeutic drug monitoring of chloramphenicol and tetracycline 7. Therapeutic drug monitoring of quinolones 8. Therapeutic drug monitoring of macrolides 9. Therapeutic drug monitoring of antimycobacterial agents 10. Conclusions References 9.
