Description
Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, summarizes the most important developments in in vitro models for predicting the permeability of drugs. This book is structured around three different approaches, summarizing the most recent achievements regarding models comprising (i) immortalized cells with an intrinsic ability to grow as monolayers when seeded in permeable supports, (ii) primary cells isolated from living organisms and directly cultured as barrier monolayers, and (iii) tissue-based models constructed with cell lines and extracellular matrix that resembles the tridimensional structure of mucosae and other biological membranes, or animal/patient-derived tissues. Each model is covered in detail, including the protocol of generation and application for specific drugs/drug delivery systems. The equivalence between in vitro cell and tissue models and in vivo conditions is discussed, highlighting how each model may provisionally resemble different drug absorption route. Chapters included in the first edition were updated with relevant data published in recent years, while four new chapters were included to reflect new emerging directions and trends in drug permeability models.Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, is a critical reference for drug discovery and drug formulation scientists interested in delivery systems intended for the administration of drugs through mucosal routes and other important tissue barriers (e.g. the BBB). Researchers studying mucosal biology can use this book to familiarize themselves and exploit the synergic effect of mucosal delivery systems and biomolecules.- Summarizes the current advances in the use of permeability models in drug transport- Covers the most important buccal, gastric, intestinal, pulmonary, nasal, vaginal, ocular, renal, skin, and blood–brain barrier in vitro models. Includes case studies to facilitate understanding of various concepts in computer-aided applications- Updates in the second edition include organ-on-chip devices, 3D advanced models (multiple layered tissues, organoids, etc.), and multicompartmentalized tissue models
Table of Contents
1. Introduction2. Importance and applications of cell- and tissue-based in vitro models for drug permeability screening in earlystages of drug developmentSection I: Cell-based in vitro culture models for drug permeability studies: Immortalized and primary isolated cells3.1. Cell-based in vitro models for buccal permeability studies3.2. Cell-based in vitro models for gastric permeability studies3.3. Cell-based in vitro models for intestinal permeability studies3.4. Cell-based in vitro models for nasal permeability studies3.5. Cell-based in vitro models for pulmonary permeability studies3.6. Cell-based in vitro models for vaginal permeability studies3.7. Cell-based in vitro models for transcorneal permeability studies3.8. Cell-based in vitro models for dermal permeability studies3.9. Tissue-based in vitro and ex vivo models for bloodebrain barrier permeability studies3.10. Cell-based in vitro models for placental barrier permeability studiesSection II: Tissue-based in vitro and ex vivo models for drug permeability studies4.1. Tissue-based in-vitro models for buccal permeability studies4.2. Tissue-based in vitro and ex vivo models for intestinal permeability studies4.3. Tissue-based in vitro and ex vivo models for nasal permeability studies4.4. Tissue-based in vitro and ex vivo models for pulmonary permeability studies4.5. Tissue-based models for vaginal permeability studies4.6. Tissue-based models for ocular permeability studies4.7. Tissue-based in vitro and ex vivo models for dermal permeability studies4.8. Tissue-based in vitro and ex vivo models for bloodebrain barrier permeability studies Malgorzata Burek, Ellaine Salvador and Carola4.9. Tissue-based ex vivo models for placental barrier permeability studiesSection III: Miniaturized models for drug permeability studies5.1. Organ-on-chip models for intestinal permeability studies5.2. Organ-on-chip models for pulmonary permeability studies5.3. Organ-on-chip models for bloodebrain barrier permeability studies5.4. Organ-on-chip models for other mucosal permeability studiesSection IV: Complex models for drug permeability studies6.1. Multicompartmental dynamic models for permeability studies6.2. Organoid-based models for permeability studies7. Correlation between cell- and tissue-based in vitro models for drug permeability screening with in vivo situation: modeling and functional extrapolation
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