デュボアのエリテマトーデスと関連症候群（第１０版） Dubois' Lupus Erythematosus and Related Syndromes - E-Book（10）

著者名：Wallace MD, FAAP, FACR, Daniel J. (EDT)/Hahn MD, Bevra (EDT)

Elsevier（2023/12/04発売）

• 言語：ENG
• ISBN：9780323932325
• eISBN：9780323933490

Description

For more than 50 years, Dubois' Lupus Erythematosus and Related Syndromes has been recognized internationally as the go-to clinical reference on lupus and other connective tissue diseases. From basic scientific principles to practical points of clinical management, the 10th edition provides extensive, authoritative coverage of systemic lupus erythematosus (SLE) and its related diseases in a logical, clearly written, user-friendly manner. It's an ideal resource for rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on all aspects of SLE, connective tissue diseases, and the antiphospholipid syndromes.- Provides complete clinical coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education.- Includes significant new content throughout: a new chapter on the endocrine system and hormones; newly distinct chapters on the heart and lung; new content on social disparities in lupus, clinical presentation of nephritis, and pulmonary hypertension; a new concluding chapter on future directions in the field; new basic science coverage of the microbiome, autoinflammatory, and monogenic lupus; and new coverage of diversity, inclusion, gender, compliance, and adherence.- Offers a fresh perspective from two new associate editors and many new authors with representation from 30 countries.- Contains an up-to-date overview of significant advances in cellular, molecular, and genetic technologies, including genetic advancements in identifying at-risk patients.- Discusses the clinical management of related disorders such as Sjogren's syndrome, scleroderma, polymyositis, and antiphospholipid syndrome (APS).- Presents the knowledge and expertise of international contributors to provide new global perspectives on manifestations, diagnosis, and treatment.- Features a vibrant, full-color format, with graphs, algorithms, differential diagnosis comparisons, new and improved figures, and schematic diagrams throughout.- Additional digital ancillary content may publish up to 6 weeks following the publication date.

Table of Contents

SECTION 1 What Is Lupus?1 History of Lupus2 Definition and Classification of Lupus and Lupus-Related Disorders3 The Epidemiology of LupusSECTION 2 Pathogenesis4 Overview of Lupus Pathogenesis5 Genetics of SLE6 Single Gene Defects and Autoinflammation: Relation to Lupus7 Epigenetics of Lupus8 The Role of the Environment and Microbiome in Lupus9 The Innate Immune System in SLE10 B Cells and Generation of Antibodies11 T cells12 Immunoregulatory Cells and Networks in Lupus13 Cytokines in Lupus14 Metabolic Control of Immunopathogenesis in Systemic Lupus Erythematosus15 Animal Models of Systemic Lupus Erythematosus (SLE)SECTION 3 Mechanisms of Tissue Injury16 Abnormalities in Clearance of Immune Complexes and Dying Cells in Lupus17 Complement and Systemic Lupus Erythematosus18 Apoptosis and Inflammatory Forms of Cell Death19 Tissue Damage in Lupus: Free Radicals and Fibrosis20 Lupus Nephritis21 Pathogenesis of Accelerated Atherosclerosis and Vascular Injury in Systemic Lupus Erythematosus22 Pathogenesis of Cutaneous Lupus23 Pathogenesis of Neuropsychiatric Lupus24 Pathogenesis of Sjögren SyndromeSECTION 4 Autoantibodies25 Antinuclear Antibodies, Antibodies to DNA, Histones, and Nucleosomes26 Antibodies Against Extractable Nuclear Antigens(RNP, Sm, SS-A/Ro, and SS-B/La)27 Other Autoantibodies: Antibodies to C1q, Lipoprotein, and Endothelial Cells28 Pathogenesis of Antiphospholipid Antibody Syndrome29 Drug-Induced LupusSECTION 5 Clinical Aspects of Lupus Erythematosus30 Overview and Clinical Presentation31 Skin Disease in Cutaneous Lupus Erythematosus32 The Musculoskeletal System and Bone Metabolism33 Lupus and the Cardiovascular System34 Pulmonary Manifestations of Systemic Lupus Erythematosus35 Lupus and the Nervous System: Clinical Presentation, Diagnosis, and Treatment36 Gastrointestinal and Hepatic Manifestations37 The Gut Microbiome and Lupus Pathogenesis38 Hematologic and Lymphoid Abnormalities in SLE39 Neonatal Lupus: Pathogenesis and Clinical Approaches40 Pregnancy and Reproductive Health Issues in Systemic Lupus Erythematosus41 Systemic Lupus Erythematosus in Childhood and Adolescence42 Clinical Aspects of Antiphospholipid Syndrome43 Lupus and Infections44 Ocular, Aural, and Oral Manifestations of Lupus45 Clinical Aspects of Sjögren's Disease46 Clinical Presentations of Lupus in the Kidney and Urogenital System47 The Endocrine System and Hormones in LupusSECTION 6 Assessment of Lupus48 Clinical Application of Serologic Tests, Serum Protein Abnormalities, and Other Laboratory Tests in Systemic Lupus Erythematosus49 Differential Diagnosis and Disease Associations50 Incomplete Lupus, Undifferentiated Connective Tissue Disease, and Mixed Connective Tissue Disease51 Clinical Markers, Metrics, Indices, and Clinical TrialsSECTION 7 Management of Lupus52 Principles of Therapy, Local Measures, and NSAIDs53 Antimalarial Medications54 Systemic Glucocorticoid Therapy for SLE55 Immunosuppressive Drug Therapy56 Complementary and Integrative Health Approaches57 Specialized and Niche Therapies58 Adjunctive and Preventive Measures59 Management of Cutaneous Lupus Erythematosus60 Targeted Therapies in SLE61 Management of Lupus Nephritis62 Management of Sjögren Disease SyndromeSECTION 8 Outcomes63 Socioeconomics, Disparities, and Disability64 Prognosis and Mortality of Systemic Lupus Erythematosus65 Future Directions: Therapeutics66 Expanding the Opportunities to Effectively Treat Patients: Clinical ConsiderationsIndex