Description
Neurobiology and Physiology of the Endocannabinoid System offers readers a comprehensive reference on the neurobiology of this system and the use of cannabimimetic compounds to induce neurological changes and confer symptom relief. With sections on both natural and synthetic compounds, the book's broad coverage allows readers to learn about their use with multiple conditions, as well as the working biology of the endocannabinoid system, its receptors and its ligands. This volume provides a platform for research on the effects of this system and its modulation in brain function and neurological dysfunction.- Summarizes research on the working neurobiology of the endocannabinoid system- Contains chapter abstracts, key facts, a dictionary and a summary- Covers both natural cannabinoids and synthetic or exogenous cannabimimetics- Includes conditions like headache, anxiety, stress and neuroinflammation- Discusses system modulation in the context of pain, traumatic brain injury and obesity
Table of Contents
PrefaceI. Setting the scene and introductory chapters1. Distribution of the endocannabinoid system: linking signalling and development Michaela Dvorakova and Anna Kalinovsky2. The endocannabinoid system, immunomodulation, and LPS-induced inflammation Elliot Lloyd, Nina Nguyen and Judith Hellman3. Physiology of the endocannabinoid systems: imaging and the use of positron emission tomography (PET) Claudia Poluga, Cassis Varlow, Neil Vasdev, Isabelle Boileau and Laura M. Best4. The endocannabinoid system and aging Prof. Vahid Reza Askari5. The endocannabinoid system and post traumatic stress disorder (PTSD): a new narrative Luke Ney, Kevin M. Crombie and Leah M. MayoII. Neurobiology of the endocannabinoid system6. The protective effect of the endocannabinoid system in neurotoxin induced damage to hippocampal neurons: a focus on light and electron microscopy Rita Yakovlevna Gordon, Valentina Kitchigina and Irina Mikheeva7. Endocannabinoid Signaling and excitatory and inhibitory synapses Jian Liang and Corette J. Wierenga8. The endocannabinoids and potassium channels: an updated narrative Yu-Fung Lin9. Social interactions and neural activity: linking cellular studies and endocannabinoid signalling Cheryl McCormick10. Exercise and Parkinson's disease: linking in the cannabinoid type 1 (CB1) and type 2 (CB2), and mu-opioid receptors Marucia Chacur Sr., Caroline Cristiano Real Gregório and Karina Henrique Binda11. Endocannabinoids and inhalant misuse: neuropsychological aspects John Woodward12. Fatty acid amide hydrolase (FAAH) in substance use disorders: FAAH regulation and inhibition in cannabis, alcohol, nicotine, stimulant, and opioid use disorders Garth E. Terry and Greta Niemela13. Treatment of pain with dual fatty acid amide hydrolase (FAAH) enzyme and human soluble epoxide hydrolase (sEH) enzyme inhibitors: interlinking the endocannabinoid system Stevan Pecic and Ram Kandasamy14. WWL70: linking the hydrolyses 2-arachidonoylglycerol, endocannabinoid and eicosanoid pathways: therapeutic potential and neurological disease Mikiei Tanaka and Yumin Zhang15. Endocannabinoid catabolic enzyme inhibitors and pain alleviation Sidney Stevens Negus and Clare Diester16. The endocannabinoid system in health and disease: features in epilepsy Christopher Martínez-Aguirre, Maria de los Angeles Nuñez-Lumbreras and Luisa Lilia Rocha17. The endocannabinoid system and autoimmune demyelination: a focus on multiple sclerosis Ana Bernal-Chico, Andres Baraibar, Alvaro Moreno-Garcia, Teresa Colomer, Ester Sanchez, Carmen Utrilla, Carlos Matute and Susana Mato18. Endocannabinoid signaling and the lateral habenula Jiang-Hong Ye19. On the interplay among endocannabinoid, noradrenergic and glucocorticoid systems: evidence from aversive memory studies Moisés Dos Santos Corrêa, Raquel Fornari, Cristina A. Stern, Leandro José Bertoglio and Lucas GazariniIII. Receptor biology and responses20. Adenosine A2A-cannabinoid CB1 receptor heteromers in the brain: From trans-inhibition to trans-activation Ester Aso and Francisco Ciruela21. Hippocampal CB1, CB2 receptors, the endocannabinoid system and fear memory Ana Maria Raymundi and Cristina A. Stern22. Beta-caryophyllene, the CB2 cannabinoid receptor-specific agonists and wound healing Prof. S. Koyama and Thomas Heinbockel23. The nigrostriatal dopaminergic pathway: impact of WIN 55212-2 as a potent cannaboinoid receptor agonist Enzo Perez-Valenzuela and Jose Antonio Fuentealba Evans24. Peripheral cannabinoid receptor 1 antagonists and impact on adipocytes Morvarid Kabir25. Endocannabinoid system receptors in plasma membranes : extraction, lipid rafts and the cortex Changiz Taghibiglou and Hajar Miranzadeh Mahabadi26. Applications to wound healing: cannabinoid receptor 1 antagonism and collagen deposition Inês Correia-Sa27.
