ホフマン血液学：原理と実践（第８版） Hematology E-Book : Basic Principles and Practice（8）

著者名：Hoffman MD, Ronald (EDT)/Benz MD, Edward J. (EDT)/Silberstein MD, Leslie E. (EDT)/Heslop MD, Helen (EDT)/Weitz MD, Jeffrey (EDT)/Salama MD, Mohamed E. (EDT)

Elsevier（2022/10/27発売）

• 言語：ENG
• ISBN：9780323733885
• eISBN：9780323733892

Description

Extensively revised, comprehensive content from leading global contributors ensures that Hematology, 8th Edition, remains your #1 choice for expert guidance in all areas of this rapidly advancing subspecialty. This edition reflects the numerous advances that are redefining the field and dramatically influencing new approaches to diagnosis, treatment, and outcomes. Well-illustrated and clinically focused, it details the basic science and clinical practice of hematology and hematopoietic cellular therapy—covering virtually all aspects of hematology in one definitive resource.- Covers all hematologic disorders, including comprehensive discussions of hematologic malignancies, individualized patient care, cell-based therapies, transplantation, transfusion medicine, hemostasis, thrombosis, and consultative hematology—in one convenient volume.- Provides state-of-the-art guidance from global experts at the forefront of the latest research and clinical practice.- Provides extensive updates throughout on basic science research, advances in molecular diagnostics, new drugs, immunotherapies, personalized medicine, laboratory medicine, transfusion medicine, stem cell transplantation, and clinical treatment for all hematologic malignancies and non-malignancies- Contains new chapters on gene editing; the impact of mitochondria on hematopoiesis; myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes; immunotherapy and management of its toxicities; transfusion medicine in sickle cell disease; principles of radiation therapy; and COVID-19, including complications of vaccination and its impact on the hematologic system.- Discusses many new advances in the field, including details and the future of gene therapy for hemophilia, gene editing for sickle cell disease and thalassemia, the evolution of cellular therapy, use of cells, transfusion medicine vs. protein therapy, gene sequencing, immunotherapy, and new targeted drugs.- Includes more decision-making algorithms for formulating diagnoses and personalized treatment plans for those highly complex disorders that require individualized approaches.- Addresses the effects of aging on hematopoiesis and on the manifestations of a variety of hematologic disorders.- Discusses cardio-oncology and its impact on the treatment of patients with hematologic disorders.- Presents relevant basic science as background for clinical application in later sections.- An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

Table of Contents

PART I MOLECULAR AND CELLULAR BASIS OF HEMATOLOGY1. Anatomy and Physiology of the Gene2. Epigenomics in Hematology3. Genomic Approaches to Hematology4. Regulation of Gene Expression in Hematology5. Genome Editing6. Signaling Transduction and Metabolomics7. Protein Architecture: Relationship of Form and Function8. Pharmacogenomics and Hematologic DiseasesPART II CELLULAR BASIS OF HEMATOLOGY9. Hematopoietic Stem Cell Biology10. Mitochondria and Hematopoiesis11. Cytokines, Chemokines, Other Growth Factors, and Their Receptors12. Role of Chemokines in Leukocyte Trafficking13. Stem Cell Model of Hematologic Diseases14. Hematopoietic Microenvironment15. Cell Adhesion16. Current Biology of Stem Cell Homing and Mobilization: Dynamic Interactions Between Hematopoietic Stem and Progenitor Cells and Their Surrounding Bone Marrow Microenvironment17. Control of Cell Division18. Cell Death19. Aging and HematopoiesisPART III IMMUNOLOGIC BASIS OF HEMATOLOGY20. Dendritic Cell Biology21. Natural Killer Cell Immunity and Therapy22. B-Cell Development23. Complement and Immunoglobulin Biology Leading to Clinical Translation24. T-Cell Immunity25. Unmodified Ex Vivo Expanded T Cells26. Treatment of Hematologic Malignancies with Genetically Modified T CellsPART IV DISORDERS OF HEMATOPOIETIC CELL DEVELOPMENT27. Biology of Erythropoiesis, Erythroid Differentiation, and Maturation28. Granulocytopoiesis and Monocytopoiesis29. Thrombocytopoiesis30. Inherited Bone Marrow Failure Syndromes31. Aplastic Anemia32. Paroxysmal Nocturnal Hemoglobinuria33. Acquired Disorders of Red Cell, White Cell, and Platelet ProductionPART V RED BLOOD CELLS34. Pathobiology of the Human Erythrocyte and Its Hemoglobins35. Approach to Anemia in the Adult and Child36. Iron Homeostasis and Its Disorders37. Disorders of Iron Homeostasis: Iron Deficiency and Overload38. Anemia of Chronic Inflammation39. Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias40. Megaloblastic Anemias41. Thalassemia Syndromes42. Pathobiology of Sickle Cell Disease43. Clinical Aspects of Sickle Cell Disease44. Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias45. Red Blood Cell Enzymopathies46. Red Blood Cell Membrane Disorders47. Autoimmune Hemolytic Anemia48. Extrinsic Nonimmune Hemolytic AnemiasPART VI NON-MALIGNANT LEUKOCYTES49. Neutrophilic Leukocytosis, Neutropenia, Monocytosis, and Monocytopenia50. Lymphocytosis, Lymphocytopenia, Hypergammaglobulinemia, and Hypogammaglobulinemia51. Disorders of Phagocyte Function52. Congenital Disorders of Lymphocyte Function53. Pediatric and Adult Histiocytic Disorders54. Lysosomal Storage Diseases, Focusing on Gaucher Disease: Perspectives and Principles55. Epstein-Barr Virus and Associated Lymphoproliferative ConditionsPART VII HEMATOLOGIC MALIGNANCIES56. Progress in the Classification of Hematopoietic and Lymphoid Neoplasms: Clinical Implications57. Conventional and Molecular Cytogenomic Basis of Hematologic Malignancies58. Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies59. Pathobiology of Acute Myeloid Leukemia60. Clinical Manifestations and Treatment of Acute Myeloid Leukemia61. Myelodysplastic Syndromes62. Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome in Adults63. Acute Myeloid Leukemia in Children64. Blastic Plasmacytoid Dendritic Cell Neoplasm65. Myelodysplastic Syndromes and Myeloproliferative Neoplasms in Children66. Pathobiology of Acute Lymphoblastic Leukemia67. Clinical Manifestations and Treatment of Childhood Acute Lymphoblastic Leukemia68. Acute Lymphoblastic Leukemia in Adults69. Chronic Myeloid Leukemia70. The Polycythemias71. Essential Thrombocythemia72. Primary Myelofibrosis and Chronic Neutrophilic Leukemia73. Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap Syndromes74. Eosinophilia, Eosinophilic Neoplasms, and the Hypereosinophilic Syndromes75.