Description
Toxicity and Toxicodynamics, Volume One in the Essentials of Pharmatoxicology in Drug Research series provides an overview on the essentials of toxicology, risk assessment and the mechanisms. Topics discussed include the types of cellular responses to chemical toxicants, mechanisms of drug toxicity, and their relevance to pharmaceutical product development. The book examines omics and computer-aided technologies for mechanistic and predictive toxicology and covers state-of-art testing in the evaluation of detrimental pathways, dose selection in toxicity studies, as well as the role of regulatory agencies in toxicity studies.In addition, there is also discussion on clinical interventions such as pharmacotherapy and managed care strategies for acute poisoning. This volume is a valuable resource to those learning more about the drug development process related to toxicology and those who want to get an update on newer concepts on the toxicology aspect of drug research.- Examines toxicological risk assessment in drug research- Discusses toxicity mechanisms- Covers risk assessment and the use of omics and computational technologies in mechanistic and predictive toxicology- Offers clinical interventions and managed care as a result of toxic injury and acute poisoning
Table of Contents
1. Understanding Pharmacotoxicology2. Mechanisms of Drug Toxicity and Relevance to Pharmaceutical Development3. Omics in Mechanistic and Predictive Toxicology4. Role of Micro RNAs in Toxicology5. Exosomes as Mediators of Chemical-Induced Toxicity6. Types of Cellular Responses to Chemical Toxicants7. Tissue Repair as A Key Determinant in Toxicant-Induced Injury8. Role Of "Toxicant-Induced Loss of Tolerance in the Emergence of Disease9. Computer-Aided Technologies in Drug Discovery and Toxicity Prediction10. Adverse Outcome Pathway for Chemical Toxicity11. Toxicokinetics and Organ-Specific Toxicity12. Dose Selection for Toxicity Studies13. Tissue-Based Models as A Replacement for Animal Models in Toxicity Testing14. Medication Error and its Toxicity Connection15. Idiosyncratic Toxicity16. Toxicological Risk Assessment17. Clinical Detoxification of the Body18. Principles of Management of Acute Poisoning19. Predicting Toxicity and Modes of Toxic Action from Chemical Structure20. Toxicity Labels21. Toxic Potential Indicator22. Aquatic Toxicology23. Concept of Pharmacotherapy and Managed Care in Clinical Interventions24. Psychopharmacology in Late Life: Key Challenges and Opportunities25. Regulatory Agencies for Toxicity Studies26. Key Challenges for Toxicologists in the 21st Century
