Description
The nuclear factor erythroid 2-related factor 2 (Nrf2) was described as a master regulator of the cellular antioxidant response. Moreover, many critical biological functions linked to cell viability, metabolism, autophagy, inflammation, immunity, and differentiation have been attributed to Nrf2, which regulates over 600 genes. It is well known that oxidative stress, which Nrf2 can ameliorate, plays a key role in many pathologic processes such as aging, obesity, diabetes, cancer, and neurodegenerative diseases.
Flavonoids, on the other hand, through their ability to activate and upregulate Nrf2, can have anti-oxidative, anti-inflammatory, anti-mutagenic, and anti-carcinogenic properties. Flavonoids are an essential ingredient in nutraceuticals, functional foods, and pharmaceuticals. The present book Flavonoids and Anti-Aging: The Role of Transcription Factor Nuclear Erythroid 2-Related Factor2 focuses on the interaction between Nrf2 and flavonoids and their applications in various conditions such as aging, osteoporosis, cardiovascular diseases, and neurodegenerative disease and many other areas.
Key Features:
- Focuses on the mechanisms and use of flavonoids in activating Nrf2 as an anti-aging and "WELLNESS" molecule
- Provides a specific approach to flavonoid activation of Nrf2 and its implications in aging and various disease conditions and its applications as nutraceuticals
- Presents flavonoid-based functional foods
- Discusses the flavonoid nutraceuticals market and future trends
Written by experts in the field, this book provides a unique approach to understanding the flavonoid activation of the transcription factor Nrf2, which is responsible for many different disease conditions due to increased reactive oxidative species in the body caused by some physiological triggers.
Table of Contents
- Flavonoids: Sources, Chemical Classification and
- Flavonoids classification and their applications as nutraceuticals
- Role of NRF2 in Flavonoids anticancer activity
- The Role of Nrf2 Activation and Autophagy in Aging, and Neurodegenerative Diseases,
- Role of Flavonoids Activation of Nrf2 in Neurodegenerative Disease and
- Aging, hearing loss and Nrf2
- NRF2 and ocular aging: Flavonoid and Nutraceuticals Use
- Role of NRF2 in Obesity and flavonoid action
- Flavonoids Activation of Nrf2 and Osteoporosis
- NRF2 Cardiovascular diseases and aging and Flavonoid nutraceuticals
- NRF2 The aging liver
- Flavonoids based Functional Foods
Pharmacological Activities,
Madhavi Gangapuram and Kinfe K. Redda
Augustine Nkembo
Patricia Mendonca
Elizabeth Mazzio and Karam Soliman
Brain Aging
Equar Taka, Getinet M. Adinew, Karam F. A. Soliman
Charles A Lewis
Aaron L Hillard and Tanya Russel
Seth Kwabena Amponsah, Emmanuel Boadi Amoafo and Emmanuel Kwaku Ofori
Samia Messeha
Seth Kwabena Amponsah and Emmanuel Boadi Amoafo
Aparoop Das, Kalyani Pathak, Manash Pratim Pathak, Urvashee Gogoi, Riya Saikia
Archita Jha and Yashwant V Pathak
