Description
The Regulatory Genome in Adaptation, Evolution, Development, and Disease synthesizes insights from recent genomic and gene expression studies across organisms, from humans to plants, animals, and single cell life, exploring common roles gene regulation plays in adaptive evolution, developmental biology and susceptibility to disease. The book sheds light on gene regulation across evolutionary timelines, illuminating new areas of focus and future research. Chapters consider key elements in gene expression regulation, fundamentals of genomic alterations over time, and in response to environmental and local conditions, epigenetics in adaptive evolution, and adaptive gene regulation in healthy processes and developmental biology, and in disease biology.Throughout the book, a comparative approach is adopted across organisms to highlight common evolutionary themes and genome diversity revealed by recent sequencing and GWAS studies, as well as how this informs our understanding of human adaptive evolution. The book finishes by detailing how we can use this knowledge to impact disease outcomes and healthy human metabolism, development, and physiology.- Reviews key elements in the regulation of gene expression and modes of studying gene regulation across evolutionary timelines- Adopts a cross-species view, synthesizing recent sequencing and GWAS studies across organisms to draw out fresh meaning and highlight pathways for future research- Considers altered gene expression associated with developmental defects and disease, as well as healthy biology and physiology, and our adaptive response to disease influence
Table of Contents
Part I. Progress in determining key elements in regulation of gene expression1. Gene regulation in physiological processes2. Epigenetics, the nonprotein coding genome, and human accelerated sequencesPart II. Evolution and adaptation3. Gene expression and regulation relative to specific tissues and functions4. Evo-Devo and morphological diversity5. Adaptation and evolution6. Adaptations metabolic and genomic to environmental changesPart III. Adaptation7. Regulatory elements relevant to brain, connectome, and neurodevelopmental disorders8. Altered gene expression associated with developmental defects and disease9. Metabolic, epigenetic functions and correlations with phenotype10. Aging, genomic, mitochondrial, and regulatory changesPart IV. Altered gene expression associated with developmental defects and disease 11. The regulatory genome and defects in monogenic diseases12. Epigenetics and human disease13. Connecting developmental defects and evolutionary findings14. The regulatory genome and complex common diseases
