Description
Neurons are excitable cells. They use ions and electrical signaling to talk to each to other and when they talk to each other, neurons control behavior. The Oxford Handbook of Neuronal Ion Channels is an accessible reference describing the nature and properties of ion channels in neurons. The book explains how ion channels open and close, how they can be selective for specific ions, and how they give rise to action potentials. Included are in-depth chapters discussing specific classes of ion channels: potassium channels, sodium channels, neurotransmitter-gated ion channels and other specialized channels. Throughout the handbook, important insight is provided on the contribution ion channels make to neuronal excitability and to synaptic transmission. The handbook goes further to discuss channelopathies, a group of human diseases such as epilepsy, pain and migraines that can be caused by ion channel dysfunction. For neuroscientists, biophysicists and neuropharmacologists, this handbook is a valuable reference of ion channel biology and function.
Table of Contents
Table of ContentsBasic Principles1. Excitable Membrane Properties of NeuronsLeonard K. Kaczmarek2. Ion Channel Permeation and SelectivityJuan J. Nogueira and Ben Corry3. Gating of Ion ChannelsRene Barro-SoriaVoltage-gated Channels4. The Voltage-Dependent K+ Channel FamilyHanne B. Rasmussen and James S. Trimmer5. Potassium Channel Mutations in EpilepsyElizabeth E. Palmer6. The Voltage-Dependent Sodium Channel FamilyMariola Zaleska, Samantha C. Salvage, Andrew J. Thompson, Sivakumar Namadurai, Christopher L.-H. Huang, Trevor Wilkinson, Fiona S. Cusdin, and Antony P. Jackson7. Specialized Sodium Channels in Pain TransmissionYucheng Xiao, Zifan Pei, and Theodore R. Cummins8. Sodium Channelopathies of the Central Nervous SystemPaul G. DeCaen, Alfred L. George, Jr., and Christopher H. ThompsonLigand-gated Channels9. AMPA and Kainate ReceptorsG. Brent Dawe, Patricia M. G. E. Brown, and Derek Bowie10. N-Methyl-D-Aspartate ReceptorsGary J. Iacobucci and Gabriela K. Popescu11. Nicotinic Acetylcholine ReceptorsRoger L. Papke12. GABAA Receptor Physiology and PharmacologyMartin Wallner, A. Kerstin Lindemeyer, and Richard W. Olsen13. P2X ReceptorsAnnette Nicke, Thomas Grutter, and Terrance M. Egan14. Large Conductance Potassium Channels in the Nervous SystemWilly Carrasquel-Ursulaez, Yenisleidy Lorenzo, Felipe Echeverria, and Ramon Latorre15. Hyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsAlessio Masi, Maria Novella Romanelli, Guido Mannaioni, and Elisabetta CerbaiOther Channels16. Tandem Pore Domain Potassium ChannelsDouglas A. Bayliss17. TRPC Channels-- Insight from the Drosophila Light Sensitive ChannelsBen Katz, William L. Pak, and Baruch Minke18. Acid-Sensing Ion ChannelsStefan Gründer19. TMEM16 Ca2+ Activated Cl- Channels and CLC Chloride Channels and TransportersAnna Boccaccio and Michael Pusch
