Description
Reader-friendly Cell Biology, 4th Edition, provides a concise but comprehensive foundation for students entering research or health care career paths. Award winning illustrations help readers quickly grasp general principles. The authors have thoroughly updated this popular text to provide readers with the current understanding of the principles of normal cellular function along with examples of how molecular defects predispose to human disease. Major new themes in the 4th edition include the roles of intrinsically disordered polypeptides and phase separation in cellular functions, the influence of new molecular structures on understanding mechanisms, and the impact of exciting new methods—from single cell RNA sequencing to second generation super resolution fluorescence microscopy—on advancing our understanding.- Clear, readable explanations provide a concise story about how cells function at the molecular level- An intuitive chapter flow starts with genome organization, gene expression, and RNA processing as a foundation for understanding every aspect of cellular function and physiology- Brings cellular biology to life for students interested in medical science by explaining how mutations in genes can compromise virtually every cellular system and predispose to human disease. Knowledge of cell biology has led to new treatments for cancer, heart failure, cystic fibrosis, and many other diseases- Unique illustrations with realistic proportions and relationships explain every cellular process including the assembly of SARS CoV-2, the structures attaching mitotic chromosomes to microtubules, the mechanism of DNA replication and how pumps, carriers and channels orchestrate physiological processes from synaptic transmission to cellular volume regulation- Covers exciting breakthroughs such as SMC motor proteins actively organizing chromosomal DNA, TOR kinases regulating metabolism, new types of immunotherapy for cancer treatment, mechanisms regulating fast axonal transport and their relation to neurodegenerative diseases, how completion of DNA replication sets the time for cells to enter mitosis, how a cascade of signals specifies the site of cell division, and newly understood pathways of normal and pathological cell death- Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices
Table of Contents
SECTION I Introduction to Cell Biology1. Cells as the Basis of Life on Earth2. Evolution of Life on EarthSECTION II Chemical and Physical Background3. Molecules: Structures and Dynamics4. Biophysical Principles5. Macromolecular Assembly6. Research StrategiesSECTION III Chromatin, Chromosomes, and the Cell Nucleus7. Chromosome Organization8. DNA Packaging in Chromatin and Chromosomes9. Nuclear Structure and DynamicsSECTION IV Central Dogma: From Gene to Protein10. Gene Expression11. Eukaryotic RNA Processing12. Protein Synthesis and FoldingSECTION V Membrane Structure and Function13. Membrane Structure and Dynamics14. Membrane Pumps15. Membrane Carriers16. Membrane Channels17. Membrane PhysiologySECTION VI Cellular Organelles and Membrane Trafficking18. Posttranslational Targeting of Proteins19. Mitochondria, Chloroplasts, Peroxisomes20. Endoplasmic Reticulum21. Mechanisms of Vesicular Transport22. Secretory Membrane System and Golgi Apparatus23. Endocytosis and the Endosomal Membrane System24. Processing and Degradation of Cellular ComponentsSECTION VII Signaling Mechanisms25. Plasma Membrane Receptors26. Protein Hardware for Signaling27. Second Messengers28. Integration of SignalsSECTION VIII Cellular Adhesion and the Extracellular Matrix29. Cells of the Extracellular Matrix and Immune Systems of Animals30. Extracellular Matrix Molecules31. Cellular Adhesion32. Intercellular Junctions33. Connective TissuesSECTION IX Cytoskeleton and Cellular Motility34. Actin and Actin-Binding Proteins35. Microtubules and Centrosomes36. Intermediate Filaments37. Motor Proteins38. Intracellular Motility39. Cellular Motility40. MusclesSECTION X Cell Cycle41. Introduction to the Cell Cycle42. G1 Phase and Regulation of Cell Proliferation,43. S Phase and DNA Replication44. G2 Phase: Responses to DNA Damage and Control of Entry Into Mitosis45. Mitosis46. Cytokinesis47. Meiosis48. Cell Death
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