Description
Anti-Aging Pharmacology provides an overview of current research aimed at the pharmacological modulation of aging, including a discussion of the growing number of novel drug classes with promising anti-aging potential. The aging process is the main risk factor for all chronic diseases affecting the elderly. With lifespans extending across the globe, these chronic diseases are placing a larger burden on individuals and health care systems. Therefore, slowing down the aging rate could be more effective in delaying aging-associated chronic disorders than combating them one by one, which is the conventional approach in a current disease-based pharmacological paradigm.This book contains the work of the world's leading researchers in the field, including sections on the conceptual and methodological background of anti-aging pharmacology, the basic classes of anti-aging drugs, phytochemicals, outcomes of anti-aging developments and future directions. This book will be of interest to a wide audience, ranging from pharmacologists, medicinal chemists and academic researchers in gerontology, biomedical sciences and those in medical practice.- Includes updated information about current developments in anti-aging pharmacology- Offers practical advice on the applicability of certain healthspan-promoting medications- Discusses potential challenges related to the translation of anti-aging drugs in clinical practice
Table of Contents
SECTION I. Conceptual and Methodological Backgrounds 1. Can Aging be Cured as a Disease?2. Geroscience Conceipt3. Mechanistic Pathways of Aging4. Biomarkers of Aging Rate5. Artificial Intelligence-Based Approach in Anti-Aging Pharmacology6. Big Data Approach7. OMICs ApproachesSECTION II. Basic Classes of Anti-Aging Drugs8. Antioxidant Paradox9. Melatonin10. Calorie Restriction Mimetics11. Metformin12. Rapamycin and rapalogs13. Nonsteroidal Anti-Inflammatory Drugs14. Statins15. Senolytics16. Epigenetic Drugs17. Sirtuin Activating Compounds18. Autophagy Inducers19. Mitophagy Modulators20. Telomerase ActivatorsSECTION III. Phytochemicals21. Resveratrol22. Curcumin23. Quercetin24. Genistein25. Epigallocatechin Gallate26. Berberine27. Nanodelivery of phytobioactive compounds: a promise in anti-aging medicineSECTION IV. Outcomes and Concluding Thoughts28. Ethical perspectives on advances in biogerontology29. Implications for Public Health Policy30. The Business of Anti-Aging Science
