Description
It's time to examine the human history of viruses, vaccines, and antiviral drugs...Public response to the COVID-19 pandemic has demonstrated that misinformation about viruses is widespread. Vaccine skepticism is rampant, and many people have been quick to accept bogus claims unsupported by science. In his latest book, Jie Jack Li sets the record straight by revealing the science and history behind antiviral drugs.Conquest of Invisible Enemies: A Human History of Antiviral Drugs guides readers through the history of viruses, vaccinations, and treatments. Readers learn about the discovery of viruses and diseases, such as HIV/AIDS, hepatitis, influenza, and SARS-CoV-2 (COVID-19). The first chapter takes an expansive look at how viruses have shaped human history. Subsequent chapters narrow in on specific viruses, diseases, and drug treatments. For example, chapter four, on influenza, looks at the 1918 Spanish flu pandemic, the history of vaccination efforts, and influenza drugs and vaccines today. Chapter five, on coronaviruses, considers drug treatments for SARS, MERS, and SARS-CoV-2. It also discusses the development of COVID-19 vaccines and drugs.Conquest of Invisible Enemies: A Human History of Antiviral Drugs focuses on the human drama behind drug discovery. Written in an engaging and accessible style, Li's timely book dispels common misconceptions about viruses and treatments and places the COVID-19 pandemic in historical context.
Table of Contents
PrefaceChapter 1. Virus Shaping History and Discovery of Virus1.1 Virus shaping history1.1.1 Tulipomania: bubbles of bulbs1.1.2 The fall of old Mexico and Peru1.1.3 Succession of thrones1.1.4 The Louisiana Purchase1.2 Discovery of virus1.2.1 The gem theory1.2.2 Discovery of virus1.2.3 Cancer-causing viruses1.2.4 Discovery of retrovirusChapter 2. HIV/AIDS Drugs, Transforming a Death Sentence to a Chronic Disease2.1 Discovery of the virus2.1.1 A death sentence2.1.2 Discovery of HIV and the great scientific controversy2.1.3 The Nobel Prize2.2 The first ray of hope2.2.1 Nucleoside antiviral drugs2.2.2 Non-nucleoside reverse transcriptase inhibitors2.3 HIV protease inhibitors2.3.1 HIV protease2.3.2 First-generation HIV protease inhibitors2.3.3 Second-generation HIV protease inhibitors2.4 HIV integrase inhibitors2.5 HIV Entry Inhibitors2.5.1 HIV fusion inhibitors2.5.2 CCR5 inhibitors2.6 Triumph of modern medicineChapter 3. Hepatitis Drugs 3.1 Hepatitis A virus3.1.1 Discovery of hepatitis A virus3.1.2 Hepatitis A vaccines3.2 Hepatitis B virus3.2.1 Discovery of hepatitis B virus3.2.2 Hepatitis B vaccines3.2.3 Hepatitis B drugs3.3 Hepatitis C virus3.3.1 Discovery of Hepatitis C virus3.3.2 Hepatitis C virus NS3/4A protease inhibitors3.3.3 Hepatitis C virus NS5A replication complex inhibitors3.3.4 Hepatitis C virus NS5B polymerase inhibitors3.4 Triumph of modern medicinesChapter 4. Influenza: A Perennial Killer4.1 Influenza, a perennial killer4.2 A virus that changed the world: the 1918 Spanish flu pandemic4.3 Discovery of the influenza virus4.4 Influenza vaccines4.4.1 History of vaccination4.4.2 History of influenza vaccines4.4.3 Influenza vaccines today4.5 Influenza drugs4.5.1 M2 inhibitors4.5.2 Influenza virus neuraminidase inhibitors4.5.3 Cap-dependent endonuclease https://en.wikipedia.org/wiki/Ribonuclease inhibitorChapter 5. Coronaviruses5.1 Coronavirus Drugs5.1.1. SARS5.1.2. MARS5.1.3. SARS-CoV-25.2 COVID-19 Vaccines5.2.1. Pfizer/Biotech's mRNA vaccine5.2.2. Johnson & Johnson's viral vector vaccine5.3 COVID-19 Drugs5.3.1. Remdesivir (Veklury)5.3.2. DexamethasoneChapter 6. Closing RemarksBibliographyChemical Structures of Antiviral Drugs
