Description
This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of splenic pathology, it incorporates the most recent clinical, pathologic, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the 2nd edition of Diagnostic Pathology: Spleen is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource.- Provides essential knowledge focused entirely on splenic pathology, including immunohistochemistry, flow cytometry, and molecular testing as they relate to splenic lesions and their differential diagnoses- Presents up-to-date information on splenic injury and laceration grading and management, the findings of next-generation sequencing studies, and a range of molecularly defined genetic alterations of spleen neoplasms- Features an Antibody Index and Molecular Factors Index to assist with identification and diagnosis- Includes 14 new chapters covering topics such as autoimmune disease involving the spleen, spleen anatomy, splenic microcirculation, immune function of the spleen, spleen imaging, leukemic non-nodal mantle cell lymphoma, Tay-Sachs disease, normal T-cell subsets, and many others- Includes approximately 2,000 high-quality clinical and histologic images, gross pathology images, radiologic images, and full-color illustrations to help practicing and in-training pathologists reach a confident diagnosis- Includes updated criteria, terminology, and classifications from the 2017 World Health Organization Classification of Lymphoid Neoplasms- Employs consistently templated chapters, bulleted content, key facts, and annotated images for quick, expert reference at the point of care- Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices
Table of Contents
SECTION 1: HISTOLOGY, FUNCTION, AND DEVELOPMENT OF SPLEENNORMAL HISTOLOGY4 Introduction to SpleenMohammad A. Vasef, MD and Jeremy C. Wallentine, MD12 Imaging of Splenic DisordersMohammad A. Vasef, MD18 Handling, Processing, and Gross Pathology of Spleen26 Fine-Needle Aspiration and Core Biopsy of Spleen32 Immunohistochemistry of SpleenAaron Auerbach, MD, MPH40 Flow CytometryNadine Aguilera, MD46 Molecular TechniquesSECTION 2: NONNEOPLASTIC SPLENIC DISORDERSLYMPHOID HYPERPLASIA54 Florid Follicular HyperplasiaJeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH56 Autoimmune Disease62 HIV in Spleen68 Castleman Disease70 Marginal Zone HyperplasiaGRANULOMATOUS LESIONS/DISORDERS72 LipogranulomasJeffrey Vos, MD78 SarcoidosisEllina Hall, DO and Aaron Auerbach, MD, MPH82 Chronic Granulomatous DiseaseINFECTIONS86 MycobacteriosisNadine Aguilera, MD 90 Selected Bacterial InfectionsAaron Auerbach, MD, MPH 94 Candidiasis96 Histoplasmosis98 Cryptococcosis100 Coccidioidomycosis104 Pneumocystosis108 Infectious Mononucleosis112 Cytomegalovirus Infection114 Herpes Simplex Virus InfectionAaron Auerbach, MD, MPH and Nadine Aguilera, MD116 Echinococcosis120 MalariaNONINFECTIOUS CYSTS122 Epithelial Cyst124 False CystNONNEOPLASTIC VASCULAR PROCESSES126 Chronic Passive Congestion128 Infarct136 Peliosis138 Sclerosing Angiomatoid Nodular Transformation Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MDRED CELL DISORDERS144 Sickle Cell DiseaseAaron Auerbach, MD, MPH and Ellina Hall, DO146 ThalassemiaNadine Aguilera, MD and Aaron Auerbach, MD, MPH150 Hereditary Spherocytosis152 Thrombotic Thrombocytopenic PurpuraMISCELLANEOUS LESIONS/DISORDERS158 Heterotaxy Syndromes160 Congenital Splenic Abnormalities164 Extramedullary Hematopoiesis166 Gamna-Gandy Bodies168 Hemophagocytic Lymphohistiocytosis174 Immune Thrombocytopenic Purpura178 Niemann-Pick DiseaseMeenakshi A. Nandedkar, MD and Nadine Aguilera, MD184 Gaucher Disease188 Sea-Blue (Ceroid) Histiocytosis192 Gangliosidosis Lysosomal Disorder194 Therapy Effect on Spleen202 Traumatic and Nontraumatic Splenic InjuriesSECTION 3: NEOPLASTIC SPLENIC DISORDERSBENIGN MESENCHYMAL LESIONS208 Introduction to Vascular Lesions210 Hemangioma218 Lymphangioma222 Littoral Cell Angioma228 Inflammatory PseudotumorRoberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD236 Postchemotherapy Histiocyte-Rich Pseudotumor of SpleenRoberto N. Miranda, MD and L.
