Description
This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of splenic pathology, it incorporates the most recent clinical, pathologic, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the 2nd edition of Diagnostic Pathology: Spleen is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource.- Provides essential knowledge focused entirely on splenic pathology, including immunohistochemistry, flow cytometry, and molecular testing as they relate to splenic lesions and their differential diagnoses- Presents up-to-date information on splenic injury and laceration grading and management, the findings of next-generation sequencing studies, and a range of molecularly defined genetic alterations of spleen neoplasms- Features an Antibody Index and Molecular Factors Index to assist with identification and diagnosis- Includes 14 new chapters covering topics such as autoimmune disease involving the spleen, spleen anatomy, splenic microcirculation, immune function of the spleen, spleen imaging, leukemic non-nodal mantle cell lymphoma, Tay-Sachs disease, normal T-cell subsets, and many others- Includes approximately 2,000 high-quality clinical and histologic images, gross pathology images, radiologic images, and full-color illustrations to help practicing and in-training pathologists reach a confident diagnosis- Includes updated criteria, terminology, and classifications from the 2017 World Health Organization Classification of Lymphoid Neoplasms- Employs consistently templated chapters, bulleted content, key facts, and annotated images for quick, expert reference at the point of care
Table of Contents
SECTION 1: HISTOLOGY, FUNCTION, AND DEVELOPMENT OF SPLEENNORMAL HISTOLOGY4 Introduction to SpleenMohammad A. Vasef, MD and Jeremy C. Wallentine, MD12 Imaging of Splenic DisordersMohammad A. Vasef, MD18 Handling, Processing, and Gross Pathology of SpleenMohammad A. Vasef, MD26 Fine-Needle Aspiration and Core Biopsy of SpleenMohammad A. Vasef, MD32 Immunohistochemistry of SpleenAaron Auerbach, MD, MPH40 Flow CytometryNadine Aguilera, MD46 Molecular TechniquesNadine Aguilera, MDSECTION 2: NONNEOPLASTIC SPLENIC DISORDERSLYMPHOID HYPERPLASIA54 Florid Follicular HyperplasiaJeremy C. Wallentine, MD and Aaron Auerbach, MD, MPH56 Autoimmune DiseaseNadine Aguilera, MD62 HIV in SpleenNadine Aguilera, MD68 Castleman DiseaseNadine Aguilera, MD70 Marginal Zone HyperplasiaJeremy C. Wallentine, MD and Aaron Auerbach, MD, MPHGRANULOMATOUS LESIONS/DISORDERS72 LipogranulomasJeffrey Vos, MD78 SarcoidosisEllina Hall, DO and Aaron Auerbach, MD, MPH82 Chronic Granulomatous DiseaseAaron Auerbach, MD, MPHINFECTIONS86 MycobacteriosisNadine Aguilera, MD90 Selected Bacterial InfectionsAaron Auerbach, MD, MPH94 CandidiasisAaron Auerbach, MD, MPH96 HistoplasmosisNadine Aguilera, MD98 CryptococcosisNadine Aguilera, MD100 CoccidioidomycosisAaron Auerbach, MD, MPH104 PneumocystosisAaron Auerbach, MD, MPH108 Infectious MononucleosisNadine Aguilera, MD112 Cytomegalovirus InfectionNadine Aguilera, MD114 Herpes Simplex Virus InfectionAaron Auerbach, MD, MPH and Nadine Aguilera, MD116 EchinococcosisAaron Auerbach, MD, MPH120 MalariaNadine Aguilera, MDNONINFECTIOUS CYSTS122 Epithelial CystEllina Hall, DO and Aaron Auerbach, MD, MPH124 False CystEllina Hall, DO and Aaron Auerbach, MD, MPHNONNEOPLASTIC VASCULAR PROCESSES126 Chronic Passive CongestionEllina Hall, DO and Aaron Auerbach, MD, MPH128 InfarctJeffrey Vos, MD136 PeliosisEllina Hall, DO and Aaron Auerbach, MD, MPH138 Sclerosing Angiomatoid Nodular Transformation Roberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MDRED CELL DISORDERS144 Sickle Cell DiseaseAaron Auerbach, MD, MPH and Ellina Hall, DO146 ThalassemiaNadine Aguilera, MD and Aaron Auerbach, MD, MPH150 Hereditary SpherocytosisNadine Aguilera, MD152 Thrombotic Thrombocytopenic PurpuraAaron Auerbach, MD, MPHMISCELLANEOUS LESIONS/DISORDERS158 Heterotaxy SyndromesAaron Auerbach, MD, MPH160 Congenital Splenic AbnormalitiesNadine Aguilera, MD164 Extramedullary HematopoiesisEllina Hall, DO and Aaron Auerbach, MD, MPH166 Gamna-Gandy BodiesNadine Aguilera, MD168 Hemophagocytic LymphohistiocytosisNadine Aguilera, MD174 Immune Thrombocytopenic PurpuraEllina Hall, DO and Aaron Auerbach, MD, MPH178 Niemann-Pick DiseaseMeenakshi A. Nandedkar, MD and Nadine Aguilera, MD184 Gaucher DiseaseMeenakshi A. Nandedkar, MD and Nadine Aguilera, MD188 Sea-Blue (Ceroid) HistiocytosisMohammad A. Vasef, MD192 Gangliosidosis Lysosomal DisorderMohammad A. Vasef, MD194 Therapy Effect on SpleenAaron Auerbach, MD, MPH202 Traumatic and Nontraumatic Splenic InjuriesMohammad A. Vasef, MDSECTION 3: NEOPLASTIC SPLENIC DISORDERSBENIGN MESENCHYMAL LESIONS208 Introduction to Vascular LesionsNadine Aguilera, MD210 HemangiomaNadine Aguilera, MD218 LymphangiomaNadine Aguilera, MD222 Littoral Cell AngiomaNadine Aguilera, MD228 Inflammatory PseudotumorRoberto N. Miranda, MD, Mario L. Marques-Piubelli, MD, and L. Jeffrey Medeiros, MD236 Postchemotherapy Histiocyte-Rich Pseudotumor of SpleenRoberto N. Miranda, MD and L.
