Description
Mayo Clinic Cases in Neuroimmunology delivers a case-based walk-through of demyelinating, autoimmune, and other inflammatory neurologic disorders and their mimics. The authors present cases from their own extensive experience with common and rare neuroimmunologic disorders.The format of this case-based book was developed to stimulate consideration of the differential diagnosis as the reader reviews the history and examination narratives of each of the 83 cases. Videos of autoimmune movement disorders supplement the clinical descriptions, where pertinent. In addition, test results from radiology, electrophysiology, and laboratory studies are presented, and treatment and outcome data are also included. Clinical pearls and radiologic clues to assist informed diagnostic decision-making are emphasized. Each case is followed by discussion, including therapeutic guidance and key take-home points.More than 150 multiple-choice questions with answers are also given to test readers' comprehension and retention. This new addition to the Mayo Clinic Scientific Press series is a comprehensive volume on neuroimmunology that will stimulate and inform those aiming for clinical mastery.
Table of Contents
Section ICNS Demyelinating Disease (Cases 1-21)Case 1 A Woman With Subacute Painful Vision Loss Jiraporn Jitprapaikulsan, MD, M. Tariq Bhatti, MD, Eric R. Eggenberger, DO, and Marie D. Acierno, MDCase 2 Rapidly Progressive Numbness and Weakness After Soft-Tissue AbscessElia Sechi, MD, and Dean M. Wingerchuk, MDCase 3 Weakness With Neck Flexion Brian G. Weinshenker, MDCase 4 New-Onset Right-Sided Numbness and Double Vision W. Oliver Tobin, MB, BCh, BAO, PhDCase 5 Progressive Left Lower Extremity Weakness and Thoracic Spinal Cord Lesion B. Mark Keegan, MDCase 6 Progressive Spasticity With a Single Magnetic Resonance Imaging Lesion Samantha A. Banks, MD, and Eoin P. Flanagan, MB, BChCase 7 Fluctuating Vision Loss, Seizures, and Left Parieto-Occipital Mass Alicja Kalinowska-Lyszczarz, MD, PhD, W. Oliver Tobin, MB, BCh, BAO, PhD, Yong Guo, MD, PhD, and Claudia F. Lucchinetti, MDCase 8 Diffuse Pain and Abnormal Brain MRI FindingsAndrew McKeon, MB, BCh, MDCase 9 Lesions Found by Chance Dean M. Wingerchuk, MDCase 10 Encephalopathy and Quadriparesis After an Upper Respiratory Tract Infection A. Sebastian Lopez Chiriboga, MDCase 11 Severe Monocular Vision Loss Followed by Gait Difficulty Brian G. Weinshenker, MDCase 12 Multiple Sclerosis and Cognitive Impairment Cristina Valencia-Sanchez, MD, PhD, and Jonathan L. Carter, MDCase 13 New-Onset Gait Difficulty With Kappa Free Light Chains in Cerebrospinal Fluid Maria Alice V. Willrich, PhD, and Ruba S. SaadehCase 14 A Girl With Back Pain, Paresthesias, and Painful Vision Loss Cecilia Zivelonghi, MD, and Andrew McKeon, MB, BCh, MDCase 15 A Septuagenarian With Progressive HemiparesisRoman Kassa, MD, and B. Mark Keegan, MDCase 16 Recurrent Demyelinating Episodes I. Vanessa Marin Collazo, MDCase 17 Breakthrough Disease While on Multiple Sclerosis Immunomodulatory Therapy Jonathan L. Carter, MDCase 18 Highly Active Multiple Sclerosis Roman Kassa, MD, and W. Oliver Tobin, MB, BCh, BAO, PhDCase 19 Progressive Gait Difficulties I. Vanessa Marin Collazo, MDCase 20 Progressive Cerebellar Ataxia After Natalizumab Treatment Michel Toledano, MDCase 21 Weakness and Dysarthria After Radiosurgery Andrew McKeon, MB, ChB, MDSection IIAutoimmune Neurologic Disorders (Cases 22-52)Case 22 Fatigue, Blurry Vision, and Swollen Optic Nerves Marie D. Acierno, MD, M. Tariq Bhatti, MD, John J. Chen, MD, PhD, and Eric R. Eggenberger, DOCase 23 Progressive, Symmetrical, Painless Visual Loss in an Elderly Woman Eric R. Eggenberger, DO, Marie D. Acierno, MD, M. Tariq Bhatti, MD, and John J. Chen, MD, PhDCase 24 Personality Changes, Cognitive Decline, and Jerking Movements A. Sebastian Lopez Chiriboga, MDCase 25 Rapidly Progressive Memory Loss, Mood Change, Mutism, and Abnormal Movements Shailee S. Shah, MD, and Marie F. Grill, MDCase 26 Behavioral and Cognitive Changes Followed by Coma Anastasia Zekeridou, MD, PhDCase 27 Episodic Hemiparesis, Cognitive Decline, and Seizures in a Woman With Pernicious Anemia Cristina Valencia-Sanchez, MD, PhD, and Andrew McKeon, MB, BCh, MDCase 28 Rapidly Progressive Dementia and Thyroid AntibodiesAmy C. Kunchok, MBBS, MMED, and Eoin P. Flanagan, MB, BChCase 29 Goosebumps and Memory LossJeffrey W. Britton, MD, Bhavya Narapureddy, MBBS, and Divyanshu Dubey, MBBSCase 30 A Patient With Headache and Progressive TremorAnastasia Zekeridou, MDCase 31 A Man With Flulike Symptoms and Hemorrhagic Brain LesionsMichel Toledano, MDCase 32 Hearing Loss, Imbalance, and Diplopia in a 44-Year-Old Man Michelle F. Devine, MD, Divyanshu Dubey, MBBS, and Sean J. Pittock, MDCase 33 Chorea, Ataxia, and Disturbed Sleep John C. Feemster, and Erik K. St. Louis, MD, MSCase 34 Rapidly Progressive Gait and Coordination Difficulties Andrew McKeon, MB, BCh, MDCase 35 Dancelike Movements in a Patient With a History of RashAndrew McKeon, MB, BCh, MDCase 36 Body Spasms in a Woman With Thyroid DiseaseAndrew McKeon, MB, BCh, MDCase 37 Stiffness, Spasms, and Frequent Falls in a 41-Year-Old ManMichelle Devine, MD, and A. Sebastian Lopez Chiriboga, MDCase 38 Rapid-Onset Weakness and Numbness in a Patient With Systemic Lupus Erythematosus Floranne C. Ernste, MDCase 39 Progressive Quadriparesis and Cancer Elia Sechi, MD, and Eoin P. Flanagan, MB, BChCase 40 Progressive Numbness, Burning Pain, Imbalance, and DrynessShahar Shelly, MD, and Divyanshu Dubey, MBBSCase 41 Ascending Painful Paresthesias, Progressive Ataxia, and Bilateral Foot DropRocio Vazquez Do Campo, MD, and Divyanshu Dubey, MBBSCase 42 Painless, Symmetric, Ascending Weakness and Sensory Loss Christopher J. Klein, MDCase 43 Difficult-to-Treat Polyradiculoneuropathy Marcus V. R. Pinto, MD, MS, and P. James B. Dyck, MDCase 44 Autoimmune Peripheral Nervous System Hyperexcitability Christopher J. Klein, MDCase 45 Orthostatism, Constipation, and Early Satiety Kamal Shouman, MD, and Eduardo E. Benarroch, MDCase 46 Constipation and Syncope Michelle F. Devine, MD, and Sean J. Pittock, MDCase 47 Bulbar-Predominant Weakness Jennifer A. Tracy, MD, and Vanda A. Lennon, MD, PhDCase 48 Difficulty Climbing the Stairs Anastasia Zekeridou, MD, PhD, and Vanda A. Lennon, MD, PhDCase 49 Rapidly Progressive Proximal WeaknessTeerin Liewluck, MD, and Margherita Milone, MD, PhDCase 50 Progressive Weakness and Rash Margherita Milone, MD, PhD, and Teerin Liewluck, MDCase 51 "Restlessness" After Cancer Diagnosis and Treatment Anastasia Zekeridou, MD, PhDCase 52 Sudden Onset of Diplopia and a Skeletal Muscle Antibody John R. Mills, PhDSection IIIOther Inflammatory CNS Disorders and Neuroimmunologic Mimics (Cases 53-83)Case 53 Diplopia, Orbital Pain, and Vision Loss in a Middle-Aged Woman Lauren M. Webb, and Eoin P. Flanagan, MB, BChCase 54 A Young Man With Visual Field Loss, Decreased Hearing, and Confusion M. Tariq Bhatti, MD, Eric R. Eggenberger, DO, Marie D. Acierno, MD, and John J. Chen, MD, PhDCase 55 A Woman With Progressive Gait Difficulty and White Matter Abnormalities Adrian Budhram, MD, and Ralitza H. Gavrilova, MDCase 56 Progressive Asymmetrical Limb Impairment and Cognitive Decline With Leukoencephalopathy B. Mark Keegan, MDCase 57 A Woman With Fever, Confusion, and Seizures Michel Toledano, MDCase 58 Encephalopathy With Alternating Hemispheric MRI Abnormalities Andrew McKeon, MB, BCh, MDCase 59 Rapid-Onset Hemibody Sensory Loss, Incoordination, and Muscle JerkingAndrew McKeon, MB, BCh, MD, and Nicholas L. Zalewski, MDCase 60 A History of Sarcoidosis and a New Brain Lesion Andrew McKeon, MB, BCh, MD, and Julie E. Hammack, MDCase 61 Headache and Hemiparesis in Middle Age Catalina Sanchez Alvarez, MD, and Kenneth J. Warrington, MDCase 62 Subacute Cognitive Decline in an 86-Year-Old Woman With Prior Lobar Intracerebral Hemorrhage Stephen W. English Jr, MD, MBA, and James P. Klaas, MDCase 63 A 75-Year-Old Man With 5 Days of Progressive Gait Difficulties and Confusion Julie E. Hammack, MDCase 64 Night Sweats and Paraparesis David N. Abarbanel, MD, and Ivan D. Carabenciov, MDCase 65 A Woman With Headaches and a Tumefactive Brain Lesion Andrew McKeon, MB, BCh, MDCase 66 Behavioral Change, Seizures, and Temporal Lobe Lesion Stuart J. McCarter, MD, and Andrew McKeon, MB, BCh, MDCase 67 A Young Woman With Vessel Dissection and Brainstem Lesions Burcu Zeydan, MD, and Orhun H. Kantarci, MDCase 68 Headache, Uveitis, and Leptomeningeal Enhancement Orhun H. Kantarci, MDCase 69 Weakness and Punctate Enhancement W. Oliver Tobin, MB, BCh, BAO, PhDCase 70 Bilateral Paresthesias in Crohn Disease Amy C. Kunchok, MBBS, and Andrew McKeon, MB, BCh, MDCase 71 Seizures and Enhancing Brain LesionsJosephe Archie Honorat, MD, PhD, and Andrew McKeon, MB, BCh, MDCase 72 A Man With Recurrent Headache and Focal Neurologic Deficits Jaclyn R. Duvall, MD, and Jerry W. Swanson, MD, MHPECase 73 Headache, Radicular Pain, and Enhancing Lesions W. Oliver Tobin, MB, BCh, BAO, PhDCase 74 Seizures 3 Months After Endarterectomy Andrew McKeon, MB, BCh, MD, and Robert D. Brown Jr, MD, MPHCase 75 Progressive Bilateral Arm Pain, Gait Disturbance, Constipation, and Urinary Retention Ivan D. Carabenciov, MD, and Michael W. Ruff, MDCase 76 A Woman With Subacute Numbness of the Trunk, Arms, and Legs Eoin P. Flanagan, MB, BChCase 77 A Septuagenarian With Progressive Lower Extremity Weakness and Pain Nicholas L. Zalewski, MDCase 78 Acute Quadriparesis in a Smoker Nicholas L. Zalewski, MDCase 79 A 25-Year-Old Man With Recurrent Back Pain and Rapid-Onset Paraplegia Nicholas L. Zalewski, MDCase 80 Progressive Myelopathy After Neck Pain Eoin P. Flanagan, MB, BChCase 81 Progressive Imbalance and Visual Impairment in a Patient With Diabetes Neeraj Kumar, MDCase 82 Progressive Myelopathy After Spine Surgery Andrew McKeon, MB, BCh, MD, and Nicholas L. Zalewski, MDCase 83 Altered Mental Status During the COVID-19 Pandemic Sara Mariotto, MD, Silvia Bozzetti, Maria Elena De Rui, Fulvia Mazzaferri, Andrew McKeon, MB, BCh, MD, and Sergio FerrariSection IVQuestions and AnswersSection I: Questions, Answers, Suggested ReadingSection II: Questions, Answers, Suggested ReadingSection III: Questions, Answers, Suggested Reading
