ザイプス心臓電気生理学（第８版） Zipes and Jalife's Cardiac Electrophysiology: From Cell to Bedside, E-Book（8）

著者名：Jalife MD, PhD, Jose (EDT)/Stevenson MD, William Gregory (EDT)

Elsevier（2021/12/16発売）

• 言語：ENG
• ISBN：9780323757454
• eISBN：9780323757461

Description

Fully updated from cover to cover, Zipes and Jalife's Cardiac Electrophysiology: From Cell to Bedside, 8th Edition, provides the comprehensive, multidisciplinary coverage you need—from new knowledge in basic science to the latest clinical advances in the field. Drs. José Jalife and William Gregory Stevenson lead a team of global experts who provide cutting-edge content and step-by-step instructions for all aspects of cardiac electrophysiology.- Packs each chapter with the latest information necessary for optimal basic research as well as patient care.- Covers new technologies such as CRISPR, protein research, improved cardiac imaging, optical mapping, and wearable devices.- Contains significant updates in the areas of molecular biology and genetics, iPSCs (induced pluripotent stem cells), embryonic stem cells, precision medicine, antiarrhythmic drug therapy, cardiac mapping with advanced techniques, and ablation technologies including stereotactic radioablation.- Includes 47 new chapters covering both basic science and clinical topics.- Discusses extensive recent progress in the understanding, diagnosis, and management of arrhythmias, including new clinical insights on atrial fibrillation and stroke prevention, new advances in the understanding of ventricular arrythmias in genetic disease, and advances in implantable devises and infection management.- Features 1,600 high-quality photographs, anatomic and radiographic images, electrocardiograms, tables, algorithms, and more., with additional figures, tables, and videos online.- Recipient of a 2018 Highly Commended award from the British Medical Association.- Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Table of Contents

Section 1 STRUCTURAL AND MOLECULAR BASES OF ION CHANNEL FUNCTION1. Voltage-gated sodium channels and electrical excitability of the heart2. Voltage-gated calcium3. Voltage-gated potassium channels4. Structural and molecular bases of cardiac inward rectifier potassium channel function5. Mammalian calcium pumps in health and disease6. Structural and molecular bases of sarcoplasmic reticulum ion channel function7. Organellar ion channels and transporters8. Molecular organization, gating, and function of connexin-based gap junction channels and hemichannelsSection 2 BIOPHYSICS OF CARDIAC ION CHANNEL FUNCTION9. Structure-function relations of heterotrimetric complexes of sodium channel a and β subunits10. Regulation of cardiac calcium channels11. Inhibition of phosphoinositide 3-kinase and acquired long QT syndrome12. Structural determinants and biophysical properties of hERG1 channel gating13. Molecular regulation of cardiac inward rectifier potassium channels by pharmacologic agents14. Cardiac stretch-activated channels and mechano-electric coupling15. Biophysical properties of gap junctions16. Excitation-contraction couplingSection 3 INTERMOLECULAR INTERACTIONS AND CARDIOMYOCYTE ELECTRICAL FUNCTION17. Ion channel trafficking in the heart18. Microdomain interactions of macromolecular complexes and regulation of the sodium channel nav1.519. Fibroblast growth factor homologous factors modulate cardiac calcium channels20. Macromolecular complexes and cardiac potassium channels21. Reciprocity of cardiac sodium and potassium channels in the control of excitability and arrhythmias22. The intercalated disc: A molecular network that integrates electrical coupling, intercellular adhesion and cell excitability23. Function and dysfunction of ion channel membrane trafficking and post translational modification24. Feedback mechanisms for cardiac-specific microRNAs and cAMP signaling in electrical remodelingSection 4 CELL BIOLOGY OF CARDIAC IMPULSE INITIATION AND PROPAGATION25. Stem cell-derived nodal-like cardiomyocytes as a novel pharmacologic tool: Insights from sinoatrial node development and function26. Gene therapy and biologic pacing27. Intercellular communication and impulse propagation28. Mechanisms of normal and dysfunctional sinoatrial nodal excitability and propagation29. Cell biology of the specialized cardiac conduction system30. Cardiac remodeling and regenerationSection 5 MODELS OF CARDIAC EXCITATION31. Ionic mechanisms of atrial action potentials32. Genetic algorithms to generate dynamical complexity electrophysiological models33. Calcium signaling in cardiomyocyte dodels with realistic geometries34. Theory of rotors and arrhythmias35. Computational approaches for accurate rotor localization in the human atria36. Modeling the aging heartSection 6 NEURAL CONTROL OF CARDIAC ELECTRICAL ACTIVITY37. Innervation of the sinoatrial node38. Mechanism for altered autonomic and oxidant regulation of cardiac sodium currents.39. Pulmonary vein ganglia and the neural regulation of the heart rate40. Neural activity and atrial tachyarrhythmias41. Sympathetic innervation and cardiac arrhythmiasSection 7 ARRHYTHMIA MECHANISMS42. The molecular pathophysiology of atrial fibrillation43. Myofibroblasts, cytokines, and persistent atrial fibrillation44. Role of the autonomic nervous system in atrial fibrillation45. Rotors in human atrial fibrillation46. Body surface frequency-phase mapping of atrial fibrillation47. Panoramic mapping of atrial fibrillation from the body surface48. Mechanisms of human ventricular tachycardia and human ventricular fibrillation49. Genetics of atrial fibrillationSection 8 MOLECULAR GENETICS AND PHARMACOGENOMICS50. Mechanisms in heritable sodium channel diseases51. Genetic, ionic, and cellular mechanisms underlying the J-wave syndromes52. Inheritable potassium channel diseases53.