Description
Leon Chesley's Hypertensive Disorders in Pregnancy was initially published in 1978. Four decades later, hypertension complications in pregnancy are still a major cause of fetal and maternal morbidity and death, especially in less developed nations. It is also a leading cause of preterm birth now known to be a risk factor in remote cardiovascular disease. Despite this, hypertensive disorders remain marginally studied and management is often controversial. Chesley's Hypertensive Disorders in Pregnancy, Fifth Edition continues its tradition as one of the beacons to guide the field of preeclampsia research, recognized for its uniqueness and utility. This revision focuses on prediction, prevention, and management for clinicians, and is an essential reference text for clinical and basic investigators alike. It provides a superb analysis of the multiple topics that relate to hypertension in pregnancy, especially of preeclampsia.- Summarizes the most relevant basic and clinical studies on hypertensive disorders of pregnancy, helping researchers and students stay up-to-date- Discusses the roles of metabolic syndrome and obesity and the increasing incidence of preeclampsia- Widely acclaimed as an essential scholastic resource and enthusiastically endorsed by clinicians and scientists
Table of Contents
1. The Spectrum of Hypertensive Disorders in Pregnancy: Dr. Leon Chesley's Legacy2. Epidemiology of Pregnancy-Related Hypertension3. Genetic Factors in the Etiology of Preeclampsia/Eclampsia4. Preconceptional and Periconceptional Pathways to Preeclampsia5. Placentation and Placental Function in Normal and Preeclamptic Pregnancies6. Unbiased Approaches for Addressing the Complexities of the Placenta's Role in the Preeclampsia Syndrome7. The Immunology of Preeclampsia8. Trophoblast Extracellular Vesicles in Preeclampsia9. Angiogenesis and Preeclampsia10. Vascular Endothelial Cell Dysfunction in Preeclampsia11. Cardiovascular Alterations in Normal and Preeclamptic Pregnancy12. Cardiometabolic Antecedents of Preeclampsia13. Cerebrovascular Pathophysiology in Preeclampsia and Eclampsia14. The Kidney in Normal Pregnancy and Preeclampsia15. Salt, Aldosterone, and the Renin— Angiotensin System in Pregnancy16. Platelets, Coagulation, and the Liver17. Clinical Management and Antihypertensive Treatment of Hypertensive Disorders of Pregnancy18. Prediction and Prevention of Preeclampsia19. Long-Term Effects of Preeclampsia on Mothers and Offspring20. Animal Models Used for Investigating Pathophysiology of Preeclampsia and Identifying Therapeutic Targets21. Harmonization of Data and Biobanks for Preeclampsia Research
