Description
Advances in Chemical Proteomics provides essential concepts and recent applications on probes, tool compounds and concepts for chemical proteomics and then moves on to applications, including solid-phase reagents, fragment screening, designer compounds and protein lipidation. As the second volume in the Developments in Organic Chemistry series, each chapter is written by experts in the field. Users will find this to be a valuable reference for organic chemists and chemical biologists who are interested in developing tool compounds and reagents to measure and interrogate proteome, develop drug leads, and measure off-target effects and drug toxicity.Analytical chemists who are interested in better understanding organic chemistry behind commonly used reagents for quantitative proteomics and tools compounds in the emerging field of chemical proteomics will also benefit from this comprehensive resource on the topics presented.- Provides an ideal, introductory book to chemical proteomics for organic chemists, pharmaceutical chemists and chemical biologists- Includes advanced, recent applications and reviews in chemical proteomics- Presents valuable work by a global team of experts from the field of proteomics
Table of Contents
1. Tool compounds for mass spectrometry-based chemical proteomics2. Principles of proteomic reactions of covalent inhibitors3. Reporter tags and chemistry for probe-reacted proteins4. Chemical derivatization of peptides for quantitative proteomics5. Database-searching strategies for probe-reacted proteins in a proteome6. Solid-phase reagents for discovering inhibitors of kinases7. Fragment screening for discovering covalent probes8. Designer compounds for locational proteomics9. Chemical proteomics for exploring protein lipidation Targeting Author: Edward Tate10. Synthetic evolution of indocyanine green with the 2-nitroimidazole warhead for imaging of hypoxic tumor
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