Description
Twin and Family Studies of Epigenetics, Volume 27, the latest release in the Translational Epigenetics series, gathers expert opinions on epigenetic twin and family study research methods, recent findings across various disease areas, and future directions. The book provides in-depth coverage of epigenetics fundamentals, twin and family epigenetic study design, and the broader role of epigenetics in answering questions on the developmental origins of health and disease. Throughout the volume, twin and family studies are employed to examine causes of epigenetic variation, the relationship between epigenetic modifications and mental illness, cancers, cardiovascular disease, diabetes, obesity, high blood pressure, and more.Emerging research methods applied in twin and family studies discussed include imaging epigenetics, exposure-specific DNA methylation changes, and unravelling time trends in epigenetic effects.- Offers a practical, interdisciplinary approach across epigenetics, epidemiology and various disease specialties- Applies epigenetic twin and family studies to determine the relationship between epigenetics and mental illness, cancers, cardiovascular disease, diabetes, obesity and high blood pressure, among other diseases and disorders- Features chapter contributions from a wide range of international researchers in the field
Table of Contents
ART 1 Introduction1. Value of twin and family study designs for epigenetic research2. Evaluation and measurement of epigenetic modifications in population-based studiesPART 2 Human health applications3. Discordant monozygotic twin studies of epigenetic mechanisms in mental health4. DNA methylation and breast cancer risk: value of twin and family studies5. Twin and family studies on epigenetics and oral health6. Twin and family epigenetic studies of type 2 diabetes7. Twin and family studies on epigenetics and obesity8. DNA methylation and blood pressure in Chinese adult twins9. Twin and family studies on epigenetics of autoimmune diseases10. Twin studies on the epigenetics of selected neurological disorders and carotid artery disease11. Disease-discordant twin studies of epigenetics and cancer12. Sex differences in epigenetic profiles: The value of twin studiesPART 3 Emerging approach13. Combining twin-family designs with measured genetic variants to study the causes of epigenetic variation14. Imaging epigenetics and the radiogenomics15. DNA methylation changes specific to environmental exposures: The strengths of twin studies using cigarette smoking as an example16. Time trends in epigenetic signatures and population health risks17. Ambient air pollution and human epigenetic modifications
