Description
The essential pharmaceutics textbookOne of the world's best-known texts on pharmaceutics, Aulton's Pharmaceutics offers a complete course in one book for students in all years of undergraduate pharmacy and pharmaceutical sciences degrees.Thoroughly revised, updated and extended by experts in their fields and edited by Professors Kevin Taylor and Michael Aulton, this new edition includes the science of formulation, pharmaceutical manufacturing and drug delivery.All aspects of pharmaceutics are covered in a clear and readily accessible way and extensively illustrated throughout, providing an essential companion to the entire pharmaceutics curriculum from day one until the end of the course.- Fully updated throughout, with the addition of new chapters, to reflect advances in formulation and drug delivery science, pharmaceutical manufacturing and medicines regulation- Designed and written for newcomers to the design and manufacture of dosage forms- Relevant pharmaceutical science covered throughout- Includes the science of formulation and drug delivery- Reflects current practices and future applications of formulation and drug delivery science to small drug molecules, biotechnology products and nanomedicines- Key points boxes throughout- Over 400 online multiple choice questions
Table of Contents
Preface ....................................................................... viiContributors ............................................................. ixAcknowledgements .................................................. xiiiWhat is 'pharmaceutics'?......................................... xvKevin M.G. Taylor and Michael E. Aulton1. Design of dosage forms.................................. 1Peter York2. Dissolution and solubility ............................. 13Michael E. Aulton3. Properties of solutions ................................... 30Michael E. Aulton4. Surfaces and interfaces ................................... 39Graham Buckton5. Disperse systems.............................................. 50David Attwood6. Rheology........................................................... 81Christopher Marriott7. Kinetics ............................................................. 101Gareth R. Williams and John P. Malkinson8. Solid-state properties .................................... 114Graham Buckton9. Particle size analysis ..................................... 126Kevin M.G. Taylor10. Particle size reduction and sizeseparation....................................................... 143Michael E. Aulton11. Mixing............................................................. 156Andrew M. Twitchell12. Powder flow................................................... 172Michael E. Aulton13. Fundamentals of microbiology................... 184Lara-Marie Barnes and Geoffrey W. Hanlon14. Pharmaceutical applications ofmicrobiological techniques.......................... 208Lara-Marie Barnes and Norman A. Hodges15. Action of physical and chemical agentson microorganisms....................................... 229Lara-Marie Barnes, Geoffrey W. Hanlon andNorman A. Hodges16. Principles of sterilization ............................. 247Susannah E. Walsh, Katie Laird and Jean-YvesMaillard17. Sterilization in practice ................................ 257Jean-Yves Maillard, Katie Laird and Susannah E.Walsh18. Introduction to biopharmaceutics.............. 275Marianne Ashford and Kevin M.G. Taylor19. Gastrointestinal tract e physiology anddrug absorption............................................. 279Marianne Ashford and Kevin M.G. Taylor20. Bioavailability e physicochemical,dosage form and formulation factors ........ 297Marianne Ashford, Kevin M.G. Taylor andHala M. Fadda21. Assessment of biopharmaceuticalproperties ....................................................... 320Marianne Ashford and Kevin M.G. Taylor22. Dosage regimens ........................................... 343Soraya Dhillon and Nkiruka Umaru23. Pharmaceutical preformulation .................. 360Simon Gaisford24. Solutions ........................................................ 386Sudaxshina Murdan25. Clarification ................................................... 397Andrew M. Twitchell26. Suspensions ................................................... 407Susan A. Barker27. Emulsions and creams ................................. 424Gillian M. Eccleston28. Ointments, pastes, gels, cutaneouspatches and topical sprays........................... 453Majella E. Lane29. Powders, granules and granulation ............ 463Michael E. Aulton30. Drying............................................................. 483Michael E. Aulton and Satyanarayana Somavarapu31. Tablets and compaction............................... 501Göran Alderborn and Göran Frenning32. Modified-release oral drug delivery ............ 542Emma L. McConnell, Christine M. Madla andAbdul W. Basit33. Coating of tablets and multiparticulates ... 558Stuart C. Porter34. Continuous manufacturing of tablets ........ 574Aktham Aburub and Hala M. Fadda35. Hard capsules ................................................ 586Brian E. Jones36. Soft capsules .................................................. 599Stephen Tindal37. Dissolution testing of solid dosageforms..........................................................
