Description
The Science, Etiology and Mechanobiology of Diabetes and Its Complications presents the most comprehensive synthesis of contemporary global research on diabetes, covering a novel and unique mechanobiological perspective – addressing prevention, management and treatment of tissue, organ and body system damage associated with diabetes and its complications. The book provides a unique approach to communicating diabetes-associated symptoms and opens avenues for development of novel therapeutic and preventive methods. It offers descriptive pathophysiology of diabetes and its complications with great emphasis on mechanobiology. Content coverage also includes management of tissue, organ and body system damage caused by chronic hyperglycemia.Biologists, life scientists, physicians, pharmacists, biomedical engineers, medical physicists, biomathematicians and computer scientists who are interested in the state-of-science and current challenges in the mechanobiology of diabetes should find this book very useful. Likewise, medical researchers in fields such as endocrinology, cardiovascular medicine, oncology, obesity, the immune system, inflammation and wound care and others who wish to be updated about the latest achievements in this exciting arena of research will find that information here.- Covers the state-of-knowledge in diabetes research from a mechanobiological perspective, including cell death and (neural, connective, adipose, vascular, renal etc.) tissue damage cascades and healing processes- Describes state-of-the-art technology in prevention, diagnosis, prognosis and treatment of tissue, organ and body system damage caused by chronic hyperglycemia and diabetes- Explores emerging research directions and future technology trends in the field of diabetes prevention and care, including common complications of diabetes (foot ulcers and amputation, peripheral neuropathy, retinal damage, renal damage, vascular and cardiac damage, connective tissue damage etc.) at the early stage of research and development in academia and industry
Table of Contents
1. Heel ulcers in patients with diabetes Michael Clark2. Diabetic foot ulcers and their wound Management Norihiko Ohura, Katsuya Hisamichi3. Computational modeling of the plantar tissue stresses induced by the clinical practice of off-loading of the diabetic footHadar Shaulian, Amit Gefen, Alon Wolf4. Modeling effects of sustained bodyweight forces on adipose tissue microstructures and adipocytes in diabesityMaayan Lustig, Golan Amrani, Adi Lustig, Liran Azaria, Raz Margi, Yoni Koren, Avraham Kolel, Nurit Bar-Shai, Avior Exsol, Maya Atias, Amit Gefen5. Mechanisms underlying vascular stiffening in obesity, insulin resistance, and type 2 diabetesMichael A. Hill, Yan Yang, Zhe Sun, Liping Zhang, James R. Sowers6. Pathomechanics of diabetic foot ulceration: revisiting plantar shear and temperatureMetin Yavuz7. Novel technologies for detection and prevention of diabetic foot ulcersNeil D. Reeves, Bill Cassidy, Caroline A. Abbott, Moi Hoon Yap8. The role of tissue biomechanics in improving the clinical management of diabetic foot ulcersPanagiotis Chatzistergos, Roozbeh Naemi, Nachiappan Chockalingam9. The mechanobiology of adipocytes in the context of diabetes: much more than a fat depotShirley L. Yitzhak-David, Daphne Weihs10. Optical Coherence Tomography to determine and visualize pathological skin structure changes caused by diabetesRaman Maiti, Roger Lewis, Daniel Parker, Matt J. Carré11. Effects of hyperglycemia and mechanical stimulations on differentiation fate of mesenchymal stem cellsTasneem Bouzid, Jung Yul Lim12. Clinical complications of tendon tissue mechanics due to collagen crosslinking in diabetesJennifer A. Zellers, Jeremy D. Eekhoff, Simon Y. Tang, Mary K. Hastings, Spencer P. Lake13. A phenomenological dashpot model for morphoelasticity for the contraction of scarsF.j. Vermolen14. Mechanobiology of diabetes and its complications: from mechanisms to effective mechanotherapiesChenyu Huang, Rei Ogawa15. Application of tissue mechanics to clinical management of risk in the diabetic footDaniel Parker, Farina Hashmi16. Bone carriers in diabetic foot osteomyelitisCristian Nicoletti17. Vascular mechanobiology and metabolismSarah Basehore, Jonathan Garcia, Alisa Morss Clyne18. Effect of type 2 diabetes on bone cell behaviorRachana Vaidya, Anna Church, Lamya Karim19. What makes a good device for the diabetic footEvan Call, Darren F. Groberg, Nick Santamaria20. Allostasis: a conceptual framework to better understand and prevent diabetic foot ulcersLaurel Tanner, Craig Oberg, Evan Call21. Footwear for persons with diabetes at high risk for foot ulceration: offloading, effectiveness, and costs Sicco A. Bus22. Compounding effects of diabetes in vessel formation in microvessel fragmentebased engineered constructsOmar Mourad, Blessing Nkennor, Sara S. Nunes23. Dressing selection challenges in diabetic foot local treatmentPaulo Alves, Tania Manuel, Nuno Mendes, Emília Ribeiro, Anabela Moura
