Description
Handbook of the Biology of Aging, Ninth Edition, provides a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology. The book focuses on the trend of 'big data' approaches in the biological sciences, presenting new strategies to analyze, interpret and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and metabolomics methodologies applied to aging related problems. Sections cover longevity pathways and interventions that modulate aging, innovative tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, and much more.- Assists researchers in keeping abreast of research and clinical findings outside their subdiscipline- Helps medical, behavioral and social gerontologists understand what basic scientists and clinicians are discovering- Includes new chapters on genetics, evolutionary biology, bone aging, and epigenetic control- Examines the diverse research being conducted in the study of the biology of aging
Table of Contents
Part I: Basic mechanisms, underlying physiological changes, model organisms and interventions1. Longevity as a complex genetic trait2. DNA damage and repair in aging3. Mechanisms of cell senescence in aging4. The nature of aging and the geroscience hypothesis5. Sirtuins, healthspan, and longevity in mammals6. Integrative genomics of aging7. Thermogenesis and aging8. Yeast as a model organism for aging research9. Model organisms (invertebrates)10. NIA Interventions Testing Program: A collaborative approach for investigating interventions to promote healthy aging11. Aging in nonhuman primatesPart II: Organ systems in humans and other animals, human health and longevity12. Senotherapeutics: Experimental therapy of cellular senescence13. The role of neurosensory systems in the modulation of aging14. Aging of the sensory systems: hearing and vision disorders15. Cardiac aging16. The aging immune system: Dysregulation, compensatory mechanisms, and prospects for intervention17. Microbiome changes in aging18. Lipidomics of aging19. Trends in morbidity, healthy life expectancy, and the compression of morbidity
