Description
The Design and Development of Novel Drugs and Vaccines: Principles and Protocols presents both in silico methods and experimental protocols for vaccine and drug design and development, critically reviewing the most current research and emphasizing approaches and technologies that accelerate and lower the cost of product development. Sections review the technologies and approaches used to identify, characterize and establish a protein as a new drug and vaccine target, cover several molecular methods for in vitro studies of the desired target, and present various physiological parameters for in vivo studies. The book includes preclinical trials and research, along with information on FDA approval.- Covers both in silico methods and experimental protocols for vaccine and drug development in a single, accessible volume- Offers a holistic accounting of how developments in bioinformatics and large experimental datasets can be used in the development of vaccines and drugs- Shows researchers the entire gamut of current therapies, ranging from computational inputs to animal studies- Reviews the most current, cutting-edge research available on vaccine and drug design and development
Table of Contents
1. Introduction of structural bioinformatics with respect to drug discovery2. Target identification and validation3. Retrieval of compounds4. Lead identification and optimization5. Molecular dynamics simulations6. An overview of vaccine design7. Key steps in the selection of vaccine targets8. Epitope prediction and selection of linkers and adjuvant9. Design of vaccine constructs10. In-silico validation through protein-protein docking11. Molecular cloning12. Protein expression13. Protein purification and desalting14. Biological assay15. Biophysical methods16. Outline of animal study for lead/ vaccine testing17. Evaluation of immunogenicity of vaccine candidate18. In-vitro evaluation of lead molecule19. Medical physiological parameter for lead/vaccine testing20. Brief introduction of clinical research and trials21. An overview of IND, NDA, approval agencies and FDA post-marketing surveillance22. Introduction of Intellectual property rights
