Overcoming Ovarian Cancer Chemoresistance

著者名：Samimi, Goli (EDT)/Annunziata, Christina (EDT)

Academic Press（2020/11/06発売）

• 言語：ENG
• ISBN：9780128198407
• eISBN：9780128198414

Description

Overcoming Ovarian Cancer Chemoresistance presents non-overlapping review chapters that discuss the state of the field in overcoming chemoresistance of ovarian cancer and treatment options before and following recurrence, considering the genetic makeup of the ovarian cancer patient and her tumor. With the uptake of both germline and somatic gene testing, clinicians can obtain a more comprehensive understanding of ovarian tumors and this book provides information to link the genetic makeup of a tumor (or patient) with the best available treatment.The book discusses topics such as strategies to fight chemo-resistance in ovarian cancer, circulating DNA as a monitor of response, BRCA mutations, ovarian cancer stem cells, immunotherapy and vaccines. Additionally, it brings a list of promising agents at clinical and pre-clinical stage that will impact the treatment in the near future.This book is a valuable source for cancer researchers, oncologists and several members of biomedical field who need to understand how to battle chemoresistance in ovarian cancer.- Provides a comprehensive view of both biological and genetic determinants of resistance, as well as technical approaches to monitor response- Discusses genetic reversions as a unique alteration and a new field of study- Includes a chapter on upcoming and promising agents that are in the pre-clinical and early clinical space, to set the stage for future directions in the field

Table of Contents

1. Ovarian Cancer Introduction2. Ovarian Cancer Treatment3. Chemoresistance in Ovarian Cancer4. Circulating DNA as a Monitor of Response5. BRCA Mutations and Reversions (e.g. rapid autopsy)6. Ovarian Cancer Stem Cells7. Immunotherapy/Vaccines8. Models of Ovarian Cancer to Test New Agents9. Promising Agents on the Horizons