Benzodiazepines

著者名：Peppin, John

Oxford University Press（2020/10/01発売）

• 言語：ENG
• ISBN：9780197517277
• eISBN：9780197517291

Description

Developed decades ago to treat a legitimate medical need, benzodiazepines promisingly displaced less-effective and less-safe drugs, though prescribing has since exceeded their intended use and outpaced the available data. The current situation is characterized by excessive prescribing and extended utilization beyond good therapeutic practice. Evidence indicates that prolonged use of benzodiazepines causes a wide range of adverse reactions, and withdrawal can be particularly challenging. Misused, abused, diverted, and counterfeited, benzodiazepines have serious potential for substance use disorder, and are among the leading causes of drug-related overdose deaths. The Benzodiazepines Crisis sounds the alarm against the overuse of benzodiazepines, presenting an updated, evidence-based overview of this class of drugs and their negative consequences. Bringing together years of research, clinical expertise, and scientific evidence, this book aims to address a perceived lag between evidence and action in order to call for rational and dramatically reduced usage of benzodiazepines.

Table of Contents

ForewordsReid Finlayson, Lynn Webster, Bernie Silvernail, and Carrie SilvernailPrefaceJohn F. Peppin, Joseph V. Pergolizzi, Jr., Robert B. Raffa, and Steven Wright1. Introduction: Anxiety, Insomnia, and Benzodiazepines Michael M. Miller John Peppin2. The Evolution of Benzodiazepines and the 'Z' Drugs Jamie L. Hansen and Timothy J. Atkinson 3. Uses, Efficacy, and Adverse Effects of Benzodiazepines Brian Merrill and Jeffrey Guina 4. Problems with Benzodiazepine Use in the Elderly Jan Kitzen5. Benzodiazepine Receptors in the Brain Michael H. Ossipov6. Benzodiazepine Receptors in the Periphery Robert B. Raffa7. Benzodiazepine Withdrawal: Neurobiologic Aspects George F. Koob8. Benzodiazepine Withdrawal: Clinical Aspects Steven Wright9. Benzodiazepines and Pain John F. Peppin and Steven Wright10. Benzodiazepines Abuse John J. Coleman11. History of the Regulatory Control of Benzodiazepines John J. Coleman12. Guidelines and Guidances Jo Ann LeQuang13. The Benzodiazepine Legacy PatientJeffrey Guina and Brian Merrill14. Perspective John Peppin