Description
Psychotic Disorders: Comprehensive Conceptualization and Treatments emphasizes a dimensional approach to psychosis--one of the most fascinating manifestations of altered brain behavior--that cuts across a broad array of psychiatric diagnoses from schizophrenia to affective psychosis and organic disorders like epilepsy and dementias. Written by an international roster of over seventy leading experts in the field, this volume comprehensively reviews, critiques, and integrates available knowledge on the etiology, mechanisms, and treatments of psychotic disorders, and outlines ways forward in both research and clinical practice towards more objective, mechanistically-based definitions of psychotic disorders. Chapters address topics such as psychosis phenomenology, biomarkers and treatments, the overlaps and interfaces between psychiatric disorders within the psychosis dimension, and novel disease definitions. Furthermore, the volume incorporates findings on potential mechanisms, bridges between various system levels (i.e., genetic, epigenetic, molecular and cellular, brain circuit and function, psychological, social, environmental and cultural) and their interactions, as well as the potential role in causation and/or mediation in psychotic disorders. Finally, the volume outlines a broad array of treatment approaches, from the readily available (e.g., psychopharmacology, various modalities of psychotherapy) to the experimental (e.g., cognitive interventions, neuromodulation). With a concluding section of forward perspectives conjecturing future directions and related challenges, this book aspires to stimulate new knowledge, generate novel frameworks, and carry new directions forward on psychotic disorders.
Table of Contents
Section 1: Phenomenological characteristics and dimensional conceptualization of psychosis1. Conceptualization of psychosis in psychiatric nosology: past, present and the futureMatcheri S. Keshavan, John Torous, Rajiv Tandon2. Historical epistemology of the "unitary psychosis"German E. Berrios, Ivana S. Marková3. Dimensional conceptualization of psychosisKürsat Altinbas, Sinan Guloksuz, and Jim van OsTransdiagnostic dimensions of psychosis4. Applying Research Domain Criteria (RDoC) Dimensions to psychosisSarah E. Morris, Jennifer Pacheco, Charles A. Sanislow5. Schizophrenia, Schizoaffective disorder, Bipolar DisorderBarrett Kern, Sarah K. Keedy6. Psychotic symptoms in bipolar disorderMarsal Sanches, Xiang-Yang Zhang, and Jair C. Soares7. Major depressive disorder with psychotic features: confronting and resolving the dimensional challengeJohn L. Waddington, Tara Kingston, Nnamdi Nkire, Vincent Russell8. Psychosis in Personality DisordersNidhi Kapil-Pair, Yulia Landa, Marie C. Hansen, Daniel H. Vaccaro, Marianne Goodman9. Symptom network models of psychosisAdela-Maria Isvoranu, Lindy-Lou Boyette, Sinan Guloksuz, Denny BorsboomPsychosis in general medical conditions and organic brain disorders10. Organic psychosis: phenotypic deviants or clues to schizophrenia?Peter Buckley, Brian Miller11. Epilepsy and psychosisMichael R. Trimble, Kousuke Kanemoto, Dale C. Hesdorffer12. Understanding sex differences in psychosis through the exploration of hormonal contributionsLeah H. RubinSection 2: Psychosis course and lifetime manifestationsEarly Psychosis13. Clinical phenomenology of the prodrome for psychosisAlbert R. Powers III, Thomas H. McGlashan, Scott W. Woods14. Predictors of conversion to psychosisRachael G. Grazioplene, Tyrone D. Cannon15. First-episode psychosis: phenomenology, onset, course and early intervention (OPUS)Merete Nordentoft, Nikolai Albert16. Evidence based treatment and implementation for early psychosisSacha Zilkha, Iruma Bello, Hong Ngo, Samantha Jankowski, Lisa DixonPsychosis Over Life Span and Late-Life Psychosis17. Life span development of schizophrenia: symptoms, clinical course and outcomesMatt Isohanni, Jouko Miettunen, Matti Penttilä18. Phenomenological characteristics of psychosis of aging: psychosis and dementia interphaseGraham M.L. Eglit, Barton W. Palmer, Dilip V. JesteSection 3: Neurobiology of psychosisHeritability and Genetics19. Genetic neuropathology revisited: gene expression in psychosisSamuel J. Allen; Rahul Bharadwaj,, Thomas M. Hyde, Joel E. Kleinman20. Epigenomic regulation in psychosisBibi S. Kassim, Behnam Javidfar, Schahram Akbarian21. DNA modifications in schizophreniaEhsan Pishva, Bart P. F. Rutten, Jonathan Mill22. Endophenotypes: a window on the genetics of schizophreniaDavid BraffCognitive Biomarkers of psychosis23. Cognitive biomarkers of psychosisS. Kristian Hill, Richard S.E. Keefe, John A. Sweeney24. Social cognition in psychosisAmy E. Pinkham, David L. Roberts25. Self-awareness in schizophrenia: affected domains and their impactJuliet M. Silberstein, Amy E. Pinkham, Philip D. HarveyNeurophysiologic biomarkers of psychosis26. Neurophysiologic biomarkers of psychosis: Event-related potential biomarkersJudith M. Ford, Holly K. Hamilton, Katiah Llerena, Brian J. Roach, Daniel H. Mathalon27. Oculomotor biomarkers of illness, risk, and pharmacogenetic treatment effects across the psychosis spectrumJames L Reilly, Jennifer McDowell, Jeffrey Bishop, Andreas Sprenger, Rebekka LencerBrain imaging biomarkers28. Structural connectivity in psychosisAmanda E. Lyall, Johanna Seitz, Marek Kubicki29. Functional connectivity biomarkers of psychosisGodfrey Pearlson, Michael Stevens30. MR SpectroscopyAdrienne C. Lahti, Nina V. KraguljacPathophysiology of Psychosis: Neurotransmitters31. Dopaminergic mechanisms underlying psychosisOliver Howes & Michael Bloomfield32. Glutamate in the pathophysiology of schizophreniaDaniel C. Javitt33. GABAergic Mechanisms in PsychosisTakanori Hashimoto, David A Lewis34. Alteration in nicotinic receptors in psychotic disorders: molecular neurobiology and clinical relevanceRobert Freedman35. Muscarinic acetylcholine receptors in the etiology and treatment of schizophreniaM.S. Moehle, S. E. Yohn, and P. J. Conn36. Kynurenic acid in brain function and dysfunction: focus on the pathophysiology and treatment of schizophreniaRobert Schwarcz and Sophie ErhardtPathophysiology: Voltage-gated ion channels in psychosis37. Genetic Association of Voltage-gated Ion Channels with Psychotic DisordersCharles H Large38. Voltage-gated Ion channels in neural circuits implicated in psychotic disordersCharles H LargePathophysiology: Immune Mechanisms39. Inflammatory mechanisms in psychosisAnna P. McLaughlin, Carmine M. Pariante, Valeria Mondelli40. Autoimmune processes in mental disordersMarina Mané-Damas, Carolin Hoffmann, Shenghua Zong, Peter C. Molenaar, Mario Losen, Pilar Martinez-MartínezBrain circuit alterations in psychosis41. The circuitry of midbrain dopamine system dysregulation in schizophreniaFelipe V. Gomes, Eric C. Zimmerman, Anthony A. Grace42. Feeling and remembering: effects of psychosis on the structure and function of the amygdala and hippocampusM.D. Bauman, J.D. Ragland, C.M. Schumann43. The cerebellum in psychosisKelsey Heslin, Joe Shaffer, Albert Powers, Nancy Andreasen, and Krystal ParkerSection 4: Socio-environmental mechanistic factors in psychosisEarly life adversity44. Perinatal factors in psychosisMary Clarke, Mary Cannon45. The role of early life experience in psychosisRichard P. Bentall46. Socio-environmental adversity across the life spanPeter Bosanac, David Castle47. Migration, ethnicity, and psychosesCraig MorganPsychological mechanisms and psychosis48. Cognitive and emotional processes in psychosisSteffen Moritz, Thies Lüdtke, Lukasz Gaweda, Jakob Scheunemann, and Ryan P. Balzan49. Aberrant salience attribution and psychosisToby T. Winton- Brown and Shitij KapurNeural correlates of socio-environmental risk and psychosis50. Neural correlates of childhood traumaAlaptagin Khan, Kyoko Ohashi, Maria Maierd, Martin H. Teicher51. Neural correlates of urban risk environmentsImke L.J. Lemmers-Jansen, Anne-Kathrin J. Fett, Lydia Krabbendam52. Neural correlates of ethnic minority position and risk for psychosisJean-Paul Selten, Jan Booij, Bauke Buwalda, Andreas Meyer-Lindenberg53. Resilience in psychosis spectrum disorderLotta-Katrin Pries, Sinan Guloksuz, Bart P. F. RuttenSection 5: Treatment of psychotic disordersPharmacological Treatments54. Pharmacological approaches to treatmentStefan Leucht, Andrea Cipriani, Toshi A. Furukawa55. Animal models of psychosis: approaches and validityDaniel ScottPsychological treatments in psychosis56. Psychoanalytic treatment of psychosisElyn R. Saks57. Cognitive-behavioral therapyTania Lincoln, Alison Brabban58. Psychoeducation as an approach to treatment of severe mental illnessEmma Sophia Kay, David E. Pollio, Carol S. North59. Family Interventions in psychosisJuliana Onwumere, Elizabeth Kuipers60. Peer support for people with psychiatric illness: A comprehensive reviewChyrell D. Bellamy, Anne S. Klee, Xavier Cornejo, Kimberly Guy, Mark Costa, Larry Davidson61. Mind-body approaches, mindfulnessLouise Johns, Mark Hayward, Clara Strauss, Eric Morris62. Hearing voices groupsAlison Branitsky, Eleanor Longden and Dirk Corstens63. AVATAR Therapy: a new digital therapy for Auditory Verbal HallucinationsTom K.J. Craig, Mar Rus-Calafell64. Health in a connected worldPhilippe Delespaul and Catherine van Zelst65. Recovery-oriented servicesMike Slade, Eleanor Longden, Julie Repper, Samson TseCognitive Remediation and Other Approaches66. Neuroscience-informed cognitive training for psychotic spectrum illnessesSophia Vinogradov, Rana Elmaghraby, Laura Pientka67. Cognitive remediation: theory, meta-analytic evidence, and practiceTil Wykes and Adam Crowther68. Noninvasive brain stimulation techniques in psychosisMarine Mondino, Frédéric Haesebaert, Jérôme BrunelinEarly interventions69. Treatment approaches in the psychosis prodromeAndrea M. Auther and Barbara A. Cornblatt70. From early intervention in psychosis to transformation of youth mental health reformAshok Malla, Patrick McGorrySection 6: Future directions and opportunities71. Future directions: making a start towards the primary prevention of psychosisRobin M Murray, Olesya Ajnakina and Marta Di Forti72. A glimpse forward regarding psychopathology of psychotic disordersWilliam T. Carpenter73. Time for change in psychosis researchBrett A. Clementz
