Chemical Approaches to the Synthesis of Peptides and Proteins

著者名：Lloyd-Williams, Paul/Albericio, Fernando/Giralt, Ernest

CRC Press（2020/08/18発売）

• 言語：ENG
• ISBN：9780849391422
• eISBN：9781000151688
• NDC分類：464

Description

Organic chemists working on the synthesis of natural products have long found a special challenge in the preparation of peptides and proteins. However, more reliable, more efficient synthetic preparation methods have been developed in recent years. This reference evaluates the most important synthesis methods available today, and also considers methods that show promise for future applications.
This text describes the state of the art in efficient synthetic methods for the synthesis of both natural and artificial large peptide and protein molecules. Subjects include an introduction to basic topics, linear solid-phase synthesis of peptides, peptide synthesis in solution, convergent solid-phase synthesis, methods for the synthesis of branched peptides, formation of disulfide bridges, and more. The book emphasizes strategies and tactics that must be considered for the successful synthesis of peptides.

Table of Contents

Introduction, Amino Acids and Peptide and Protein Structure, Amino Acid Activation and Coupling, Protection Schemes for Peptide Synthesis, The Synthesis of Peptides, Solid-Phase Peptide Synthesis, The Solid Support, Protection Schemes, Attachment of the First Amino Acid to the Solid Support, Chain Elongation, Cleavage of the Peptide from the Resin, Examples of Protein Synthesis by Linear SPPS, Peptide Synthesis in Solution, Strategic Considerations, Protection Schemes, Chain Elongation, Final Removal of Protecting Groups, Special Approaches to the Synthesis of Peptides in Solution, Examples of Peptide Synthesis in Solution, Convergent Approaches to the Synthesis of Large Peptides and Proteins, Convergent Solid-Phase Peptide Synthesis, The Coupling of Protected Peptide Segments in Solution, Coupling of Minimally Protected Peptides in Aqueous Solution, Chemical Ligation of Peptide Segments, Formation of Disulfide Bridges, Peptides with Disulfide Bridges, Protection of Cysteine in Peptide Synthesis, Chemical Methods for the Formation of Disulfide Bridges, Regioselective Disulfide Bridge Formation, Peptide Libraries, Multiple Peptide Synthesis in Parallel, Peptide Library Techniques, Examples of Peptide Library Synthesisi, Each chapter contains References