Description
The Oxford Handbook of the Neurobiology of Pain represents a state of the art overview of the rapidly developing field of pain research. As populations age, the number of people in pain is growing dramatically, with half the population living with pain. The opioid crisis has highlighted this problem. The present volume is thus very timely, providing expert overviews of many complex topics in pain research that are likely to be of interest not just to pain researchers, but also to pain clinicians who are seeking new therapeutic opportunities to develop analgesics. Many of the topics covered are of interest to neuroscientists, as pain is one of the most amenable sensations for mechanistic dissection.The present volume covers all aspects of the topic, from a history of pain through invertebrate model systems to the human genetics of pain and functional imaging. Chapters include the role of ion channels, the opioid system, the immune and sympathetic systems, as well as the mechanisms that transform acute to chronic pain. Migraine and the interplay between sleep and pain are also discussed. New technology in the form of transgenic animals, chemogenetics, optogenetics, and proteomic analyses are providing significant advances in our research and are covered as well. Demystifying pain through an understanding of its fundamental biology, as outlined in this volume, is the most direct route to ameliorating this vast human problem.
Table of Contents
About the EditorContributorsPrefaceAcknowledgments1. A History of Pain ResearchFernando Cervero and John N. Wood2. The Measurement of Pain in the Laboratory RodentJeffrey S. Mogil3. Invertebrate Models of Nociception: Learning From Flies and WormsDaniel Hesselson, Denise S. Walker, Joshua Neil Massingham, William R. Schafer, G. Gregory Neely, and Yee Lian Chew4. Human Genetics of PainJames J. Cox, Ingo Kurth, and C. Geoffrey Woods5. Dorsal Root Ganglion Neuron Types and Their Functional SpecializationEdward C. Emery and Patrik Ernfors6. The Sympathetic Nervous System and PainJudith A. Strong, Jun-Ming Zhang, and Hans-Georg Schaible7. Heat Pain and Cold PainFelix Viana and Thomas Voets8. Noxious MechanosensationPatrick Delmas, Sergiy Mikhailovych Korogod, and Bertrand Coste9. Sodium Channels and PainTheodore R. Cummins, Stephen G. Waxman, and John N. Wood10. Potassium Channels and PainJérôme Busserolles, Xavier Gasull, and Jacques Noël11. Voltage Gated Calcium Channels: Molecular Targets for Treating Chronic PainGerald W. Zamponi, Maria A. Gandini, and Terry P. Snutch12. Chloride Channels in NociceptorsUhtaek Oh and Jooyoung Jung13. Neuroimmune Interactions and PainJiahe Li and Peter M. Grace14. The Neurobiology of Pain: Development and SexMaria Fitzgerald and Michael W. Salter15. Central Nervous System Pain PathwaysAndrew J. Todd and Fan Wang16. Dorsal Horn Pain MechanismsHanns Ulrich Zeilhofer and Robert Ganley17. Visceral PainDavid C. Bulmer and Carolina Roza18. fMRI and Human Pain PerceptionGiandomenico Iannetti and A. Vania Apkarian19. Neurobiological Basis of MigrainePhilip R. Holland, Jan Hoffmann, and Peter J. Goadsby20. Effect of Sleep Loss on PainChloe Alexandre, Alban Latremoliere, and Patrick H. Finan21. Sensory Signaling Pathways in Inflammatory and Neuropathic PainHanneke L.D.M. Willemen and Niels Eijkelkamp22. The Diversity of Neuropathic PainNanna Brix Finnerup and Nadine Attal23. The Transition From Acute to Chronic PainWei-Hsin Sun, Yu-Shiuan Su, and Chih-Cheng Chen24. Cancer and PainRie Bager Hansen and Sarah Falk25. Opioids and PainChristoph Stein and Claire Gaveriaux-Ruff26. Neurotrophins, Cytokines, and PainShafaq Sikandar and Claudia Sommer27. Chemo- and Optogenetic Strategies for the Elucidation of Pain PathwaysSascha R.A. Alles, Anne-Marie Malfait, and Richard J. Miller28. Autoantibodies and Neuropathic PainJohn M. Dawes and David L. Bennett29. The Proteomics and Metabolomics of Pain - Opportunities for Systems MedicineDavid Gomez-Varela and Manuela SchmidtIndex
