Description
The use of light for probing and imaging biomedical media is promising for the development of safe, noninvasive, and inexpensive clinical imaging modalities with diagnostic ability. The advent of ultrafast lasers has enabled applications of nonlinear optical processes, which allow deeper imaging in biological tissues with higher spatial resolution. This book provides an overview of emerging novel optical imaging techniques, Gaussian beam optics, light scattering, nonlinear optics, and nonlinear optical tomography of tissues and cells. It consists of pioneering works that employ different linear and nonlinear optical imaging techniques for deep tissue imaging, including the new applications of single- and multiphoton excitation fluorescence, Raman scattering, resonance Raman spectroscopy, second harmonic generation, stimulated Raman scattering gain and loss, coherent anti-Stokes Raman spectroscopy, and near-infrared and mid-infrared supercontinuum spectroscopy. The book is a comprehensive reference of emerging deep tissue imaging techniques for researchers and students working in various disciplines.
Table of Contents
Overview of Second- and Third-Order Nonlinear Optical Processes for Deep Imaging
Sangeeta Murugkar and Robert W. Boyd
Complex Light Beams
Enrique J. Galvez
Gaussian Beam Optical Parameters in Multi-Photon Excitation Fluorescence Imaging
Lingyan Shi, Adrián Rodríguez-Contreras, and Robert R. Alfano
The Optics of Deep Optical Imaging in Tissues Using Long Wavelengths
Steven L. Jacques
Light Propagation and Interaction in Highly Scattering Media for Deep Tissue Imaging
W. B. Wang, Lingyan Shi, Luyao Lu, Laura A. Sordillo, L. Wang, S. K. Gayen, and R. R. Alfano
Application of Nonlinear Microscopy in Life Sciences
Zdenek Svindrych and Ammasi Periasamy
Smart Biomarker-Coated PbS Quantum Dots for Deeper Near-Infrared Fluorescence Imaging in the Second Optical Window
Takashi Jin, Akira Sasaki, and Yukio Imamura
Biomedical Applications in Probing Deep Tissue Using Mid-Infrared Supercontinuum Optical Biopsy
Angela B. Seddon
Light Propagation in Turbid Tissue-Like Scattering Media
Alexander Bykov, Alexander Doronin, and Igor Meglinski
Overview of the Cumulant Solution to Light Propagation Inside a Turbid Medium and Its Applications in Deep Imaging Beyond the Diffusion Approximation
Min Xu, Cai Wei, and Robert R. Alfano
Deep Imaging of Prostate Cancer Using Diffusion Reconstruction of Banana Paths with Near Infrared Prostatoscope Analyzer
Yang Pu, Wubao Wang, Min Xu, James A. Eastham, and Robert R. Alfano
Terahertz Propagation in Tissues and Its Thickness Limitation
Burcu Karagoz and Hakan Altan
Detection of Brain Tumors Using Stimulated Raman Scattering Microscopy
Spencer Lewis and Daniel Orringer
Chemical and Molecular Imaging of Deep Tissue through Photoacoustic Detection of Chemical Bond Vibrations
Yingchun Cao and Ji-Xin Cheng
Deep Tissue Imaging: Acoustic and Thermal Wave Propagation and Light Interactions in Tissue
Idan Steinberg, Asaf Shoval, Michal Balberg, Adi Sheinfeld, Michal Tepper, and Israel Gannot
Using the Transmission Matrix to Image Disordered Media
Matthieu Davy, Sylvain Gigan, and Azriel Z. Genack
