100 Years of Human Chorionic Gonadotropin : Reviews and New Perspectives

著者名：Cole, Laurence A. (EDT)/Butler, Stephen A. (EDT)

Elsevier（2020/02/07発売）

• 言語：ENG
• ISBN：9780128200506
• eISBN：9780128216095

Description

100 years of Human Chorionic Gonadotropin: Reviews and New Perspectives is a collection of articles written by some of the world's leading experts on the pregnancy hormone and cancer marker hCG. In 2019 it is difficult to ignore the effect that our understanding of hCG has had on the lives of millions of people worldwide. The hCG immunoassay, in one form or another, is now one of the most common medical tests conducted and is often the first indication that a mother-to-be is pregnant. Not only a marker of pregnancy, hCG is utilized in the diagnosis and monitoring in oncology and presents a potential target for novel cancer therapeutics.100 years ago, in 1919, Hirose was demonstrating gonadotropic functions which resulted from a chorionic factor. Over the last century this factor has become defined as hCG and more recently explored as not one molecule but a group of molecules with variable structure and variable functions in both pregnancy and cancer. hCG is a multi-faceted molecule that has clinical and therapeutic implications but can be a challenging topic for researchers and physicians alike. This text covers the different structures and functions of hCG exploring the genes and evolution of the molecule, the different protein and glycosylation structures which can exist and their effect on structure, detection and quantification.100 Years of hCG is not an attempt to recount the history of every publication on hCG, but rather a collection of reviews and new perspectives by "hCG-ologists", the term used by Hussa to describe biochemists working on HCG in the first book written on the topic over 30 years ago. Some of the authors have been around a while, some not so long, but others are just beginning their journey with a most beguiling molecule.- Provides updated information on a complex and changing subject in five sections- Reviews historical perspectives and developments over the last 100 years- Includes novel insights into the structure, function and detection of hCG in pregnancy and cancer- Includes chapters on the use of mass spectrometry to detect and quantify hCG as well as traditional immunoassays and over the counter pregnancy tests- Describes the role of hCG in pregnancy, endometrial receptivity and embryo implantation and the use in fertility treatment- Addresses the specific hyperglycosylated hCG test that can distinguish a normal term from a failing pregnancy and also screen for preeclampsia and gestational hypertension in pregnancy as well as its use as a marker and treatment target in cancer.- Includes chapters on the development and use of hCG vaccines- Includes a section on hCG and in subunits in cancer

Table of Contents

Forward- 100 Years of hCGIntroduction - 100 Years of hCG - Meet the Editors and the AuthorsSection 1 - Genes and StructureChapter 1.1 - Isolating C5 and B152 - AnecdoteChapter 1.2 - Evolutionary, structural and physiological differences between hCG and LHChapter 1.3 - hCG and Human Evolution - The Master MoleculeChapter 1.4 - Human Chorionic Gonadotropin: Different Origins, Glycoforms and Functions during PregnancyChapter 1.5 - Molecular Modelling of hCG: influence of glycosylation and nicking on molecular folding and epitope recognitionChapter 1.6 - Why is hCG GlycosylatedSection 2 - Detection and QuantitationChapter 2.1 - Detecting hCG that's not there - AnnecdoteChapter 2.2 - Quantification of hCG by MALDI ToF Mass SpectrometryChapter 2.3 - Pregnancy failures and false positive hCG testsChapter 2.4 - Home Pregnancy TestsChapter 2.5 - Human Chorionic Gonadotropin determination using mass spectrometryChapter 2.6 - Beta core fragment as a standard quality control in MALDISection 3 - Pregnancy and FertilityChapter 3.1 - hCG as an LH analogue - AnecdoteChapter 3.2 - The role of hCG in endometrial receptivity and embryo implantationChapter 3.3 - Qualitative Analysis of hCG Variants and Glycoforms in UrineChapter 3.4 - Phenotypic characterization of a transgenic mouse model overproducing hCGChapter 3.5 - The Role of Human Chorionic Gonadotropin in Reproductive MedicineChapter 3.6 - Pregnancy and hCGChapter 3.7 - My Journey with Human Chorionic Gonadotropin: development of a Unique Vaccine for control of fertilityChapter 3.8 - Evaluation of Delivery Vectors for Active Immunisation with Synthetic Peptides of hCG as a Fertility Control MethodSection 4 - Cancer and TherapyChapter 4.1 - How hCG and a failed experiment changed my life - AnecdoteChapter 4.2 - Human chorionic gonadotropin in cancer – where are we?Chapter 4.3 - LH/hCG-receptor independent activities of hCG and hCGβChapter 4.4 - The Role of the Free Beta Subunit of Human Chorionic Gonadotropin in Human MalignancyChapter 4.5 - hCG and Gestational Trophoblastic Diseases - Hydatidiform Mole and ChoriocarcinomaChapter 4.6 - Immunotherapy of Advanced Stage, Invariably Drug Resistant Cancer Expressing ectopically hCGChapter 4.7 – A Potential Cure for CancerSection 5 - ConclusionChapter 5.1 - Where has hCG research been? What is hCG research doing? Which direction will it go in the future?