This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated.
Co-signal Molecules in T Cell Activation will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science.
Part I: Basic Understanding of Co-signal Molecules in T cell activation.- Chapter 1 Co-signal molecules in T cell activation.- Chapter 2 The CD28-B7 family of co-signaling molecules.- Chapter 3 The TNF YNFR family of co-signal molecules.- Chapter 4 Signal transduction via co-stimulatory and co-inhibitory receptors.- Chapter 5 Molecular dynamics of co-signal molecules in t cell activation.- Chapter 6 Role of co-stimulatory molecules in T helper cell differentiation.- Chapter 7 Control of regulatory T cells by co-signal molecules.- Part II: Co-signal Molecules in Health and Disease.- Chapter 8 Stimulatory and inhibitory co-signals in autoimmunity.- Chapter 9 Co-signaling molecules in neurological diseases.- Chapter 10 Costimulation blockade in transplantation.- Chapter 11 Immunotherapy targeting co-signal molecules.
