Description
Machine learning and big data is hot. It is, however, virtually unused in clinical trials. This is so, because randomization is applied to even out multiple variables
Modern medical computer files often involve hundreds of variables like genes and other laboratory values, and computationally intensive methods are required
This is the first publication of clinical trials that have been systematically analyzed with machine learning. In addition, all of the machine learning analyses were tested against traditional analyses. Step by step statistics for self-assessments are included
The authors conclude, that machine learning is often more informative, and provides better sensitivities of testing than traditional analytic methods do
Table of Contents
Preface.- Traditional and Machine-Learning Methods for Efficacy Analysis.- Optimal-Scaling for Efficacy Analysis.- Ratio-Statistic for Efficacy Analysis.- Ratio-Statistic for Efficacy Analysis.- Complex-Samples for Efficacy Analysis.- Bayesian-Networks for Efficacy Analysis.- Evolutionary-Operations for Efficacy Analysis.- Automatic-Newton-Modeling for Efficacy Analysis.- High-Risk-Bins for Efficacy Analysis.- Balanced-Iterative-Reducing-Hierarchy for Efficacy Analysis.- Cluster-Analysis for Efficacy Analysis.- Multidimensional-Scaling for Efficacy Analysis.- Binary Decision-Trees for Efficacy Analysis.- Continuous Decision-Trees for Efficacy Analysis.- Automatic-Data-Mining for Efficacy Analysis.- Support-Vector-Machines for Efficacy Analysis.- Neural-Networks for Efficacy Analysis.- Ensembled-Accuracies for Efficacy Analysis.- Ensembled-Correlations for Efficacy Analysis.- Gamma-Distributionsfor Efficacy Analysis.- Validation with Big Data, a Big Issue.- Index.
