Description
Accurate Results in the Clinical Laboratory: A Guide to Error Detection and Correction, Second Edition, provides a comprehensive review of the factors leading to errors in all areas of clinical laboratory testing. This trusted guide addresses interference issues in all laboratory tests, including patient epigenetics, processes of specimen collection, enzymes and biomarkers. Clinicians and laboratory scientists will both benefit from this reference that applies discussions to both accurate specimen analysis and optimal patient care. Hence, this is the perfect reference for clinical laboratorians, from trainees, to experienced pathologists and directors.- Provides comprehensive coverage across endocrine, oncology, hematology, immunohistochemistry, immunology, serology, microbiology, and molecular testing- Includes new case studies that highlight clinical relevance and errors to avoid- Highlights the best titles published within a variety of medical specialties- Reviewed by medical librarians and content specialists, with key selections compiled in their annual list
Table of Contents
Section I: Sources of errors in clinical laboratories: An overview1. Variation, errors, and quality in the clinical laboratory2. Errors in patient preparation, specimen collection, anticoagulant and preservative use: how to avoid such pre-analytical errors3. Sample processing and specimen misidentification issues: major sources of pre-analytical errors4. Effect of patient-related factors on clinical laboratory test results5. Interferences of hemolysis, lipemia and high bilirubin on laboratory tests6. Immunoassay design7. Overview of other sources of interferences in immunoassays: prozone effect and interferences from heterophilic antibodies and autoantibodies8. Biotin interference in clinical laboratory tests: sporadic problem or a serious clinical issue?Section II: Sources of errors in clinical chemistry laboratory9. Challenges in routine clinical chemistry testing analysis of small molecules10. Challenges in routine clinical chemistry analysis: proteins and enzymes11. Challenges in endocrinology testing12. Pitfalls in testing for common tumor markersSection III: Sources of errors in therapeutic drug monitoring and toxicology13. Issues of interferences in therapeutic drug monitoring14. Limitations of immunoassays for screening of drugs of abuse in urine: issues of false positive and false negative results15. Challenges in confirmation testing for drugs of abuse16. Issues of false negative results in toxicology: difficult in detecting certain drugs and issues with detection of synthetic cathinone (bath salts), synthetic cannabinoids (spice), and other new psychoactive substances17. Ethanol determination using automated analyzers: limitations and pitfallsSection IV: Herbal medicines and laboratory testings18. Effects of herbal supplements on clinical laboratory test resultsSection V: Sources of errors in immunology laboratory19. Critical issues in hemoglobinopathy detection and serology testing for HIV and hepatitis infections20. Sources of errors in immunology and serology testingSection VI: Sources of errors in molecular, genetic and related testings21. Sources of error in molecular diagnostic analyses22. Molecular testing for targeted therapies and pharmacogenomics23. Challenges and sources of inaccuracy in biochemical genetics testingSection VII: Sources of errors in microbiology testings24. Sources of pre-analytical, analytical and post-analytical errors in the microbiology laboratorySection VIII: Sources of errors in hematology and coagulation testings25. Sources of errors in hematology testing26. Sources of errors in coagulation testing27. Sources of errors in flow cytometrySection IX: Sources of errors in transfusion medicine28. Interferences in blood bank testing29. Errors and adverse effects of blood transfusion30. Methodological issues in point of care testing devices31. Special concern: sources of inaccuracy in breath alcohol analysis
