Description
This book presents an overview of antimicrobial peptides (AMPs), their mechanisms of antimicrobial action, other activities, and various problems that must still be overcome regarding their clinical application. Divided into four major parts, the book begins with a general overview of AMPs (Part I), and subsequently discusses the various mechanisms of antimicrobial action and methods for researching them (Part 2). It then addresses a range of activities other than antimicrobial action, such as cell penetration, antisepsis, anticancer, and immunomodulatory activities (Part 3), and explores the prospects of clinical application from various standpoints such as the selective toxicity, design, and discovery of AMPs (Part 4). A huge number of AMPs have been discovered in plants, insects, and vertebrates including humans, and constitute host defense systems against invading pathogenic microorganisms. Consequently, many attempts have been made to utilize AMPs as antibiotics. AMPs could help to solve the urgent problem of drug-resistant bacteria, and are also promising with regard to sepsis and cancer therapy. Gathering a wealth of information, this book will be a bible for all those seeking to develop antibiotics, anti-sepsis, or anticancer agents based on AMPs.
Table of Contents
Part 1. Introduction.- Chapter 1. Antimicrobial peptides of multicellular organisms: My perspective.- Part 2. Mechanisms of Antimicrobial Action.- Chapter 2. Membrane permeabilization mechanisms.- Chapter 3. Elementary processes and mechanisms of interactions of antimicrobial peptides with membranes --- single GUV studies ----.- Chapter 4. The mechanisms of action of cationic antimicrobial peptides refined by novel concepts from biophysical investigations.- Chapter 5. Anionic lipid clustering model.- Chapter 6. Intracellular antimicrobial peptides targeting the protein synthesis machinery.- Part 3. Other activities of AMPs.- Chapter 7. Antimicrobial and cell-penetrating peptides: How to understand two distinct functions despite similar physicochemical properties.- Chapter 8. Synthetic anti-lipopolysaccharide peptides (SALP) as effective inhibitors of pathogen-associated molecular patterns (PAMPs).- Chapter 9. Anti-cancer activities of natural and synthetic peptides.- Chapter 10. Antimicrobial host defence peptides: Immunomodulatory functions and translational prospects.- Part 4. Towards Clinical Applications.- Chapter 11. Activity and selectivity of antimicrobial peptides: A complex interplay of multiple equilibria.- Chapter 12. Design of antimicrobial peptides: Progress made with human cathelicidin LL-37.- Chapter 13. Application of synthetic molecular evolution to the discovery of antimicrobial peptides.- Chapter 14. AMPs as anti-biofilm agents for human therapy and prophylaxis.- Chapter 15. Clinical application of AMPs.
