Description
Neurobiology of Depression: Road to Novel Therapeutics synthesizes the basic neurobiology of major depressive disorder with discussions on the most recent advances in research, including the interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and the development of novel optogenetic approaches that are changing research perspectives and revolutionizing research into depression. These basic foundational understandings on the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research are combined in this book to aid advanced students and researchers in their understanding of MDD.Depression is one of the most common mental-health disorders caused by a variety of genetic, biological, environmental and psychological factors. Major depressive disorder (MDD) is typically treated with first-line antidepressant agents that primarily target monoamine neurotransmission. However, only approximately one-third of patients with MDD achieve remission following a trial with such an antidepressant. Furthermore, MDD is a heterogeneous phenotype, and new frameworks, such as the NIMH Research Domain Criteria (RDoC) may provide a more accurate, biologically based comprehension of the symptomatic heterogeneity of this devastating illness.- Aids readers in understanding major depressive disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations- Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments, to antidepressants and novel therapeutics- Synthesizes discussions on the cellular and molecular mechanisms underlying symptoms with the clinical aspects of depression
Table of Contents
1. The Classification of Depression: Embracing Phenotypic Heterogeneity in the Era of the RDoCElizabeth D. Ballard, Ioline D. Henter and Carlos A. Zarate, Jr.2. The Role of Environmental and Psychosocial Factors in DepressionGordon Parker3. Gene-Environment Interactions and Epigenetic Mechanisms in DepressionMagdalene C. Jawahar, Catherine G. Toben and Bernhard T. Baune4. Pathophysiology of Cognitive Impairment in DepressionChristopher R. Bowie, Melissa Milanovic and Tanya Tran5. Anhedonia in Depression: Mechanisms, Assessment, and TherapeuticsTheodore P. Beauchaine, Daniel N. Klein, Erin Knapton and Aimee Zisner6. The Neurotrophic Hypothesis of Depression Revisited: New Insights and Therapeutic ImplicationsMinal Jaggar, Sashaina E. Fanibunda, Shreya Ghosh, Ronald S. Duman and Vidita A. Vaidya8. Neuro-Immune Interactions in Depression: Mechanisms and Translational ImplicationsHelena M. Abelaira, Ritele H. Silva, Anelise S. Carlessi, João Quevedo and Gislaine Z. Réus9. The Hypothalamic-Pituitary-Adrenal Axis in Depression: Molecular Regulation, Pathophysiological Role, and Translational ImplicationsTheo Rein, Oliver Ambrée, Gabriel R. Fries, Virginie Rappeneau, Ulrike Schmidt and Chadi Touma10. Intracellular Signaling Pathways Implicated in the Pathophysiology of DepressionGislaine Z. Réus, Jaqueline S. Generoso, Ana Lúcia S. Rodrigues and João Quevedo11. The Long-Lasting Neurobiological Scars of Early-Life Stress: Implications for the Neurobiology of DepressionMousa Botros, Gabrielle Hodgins and Charles B. Nemeroff12. Molecular, Cellular, and Circuit Basis of Depression Susceptibility and ResilienceMing-Hu Han, Scott J. Russo and Eric J. Nestler13. More Than a Gut Feeling: Emerging Roles of the Microbiome in the Pathophysiology and Treatment of DepressionJane A. Foster14. Optogenetics: Illuminating the Neural Circuits of DepressionMuir J. and Bagot R.C.15. Mitochondrial Dysfunction and Oxidative Stress: Relevance to the Pathophysiology and Treatment of DepressionAdrian L. Lopresti16. Obesity and Depression: Shared Pathophysiology and Translational ImplicationsLison Huet, Ines Delgado, Bruno Aouizerate, Nathalie Castanon and Lucile Capuron17. Depression and Cardiovascular Risk: Epidemiology, Mechanisms, and ImplicationsJessica Hatch and Benjamin I. Goldstein18. Poststroke Depression: Pathophysiology and Treatment StrategiesYun-Ju Lai and Louise D. McCullough19. Is Depression Associated With Accelerated Aging? Mechanisms and ImplicationsDaniel Lindqvist, Naomi M. Simon and Owen M. Wolkowitz20. Relationship Between Complicated Grief and Depression: Relevance, Etiological Mechanisms, and ImplicationsNicole J. LeBlanc, Naomi M. Simon, Charles F. Reynolds, III, M. Katherine Shear, Natalia Skritskaya and Sidney Zisook21. A Neural Circuit-Based Model for Depression Anchored in a Synthesisof Insights From Functional NeuroimagingAndrea N. Goldstein-Piekarski and Leanne M. Williams22. Could Depression be Preventable? Evidence and PerspectivesScott B. Patten23. Treating Depression in the Era of Precision Medicine: Challenges and PerspectivesMichael Musker and Ma-Li Wong24. Neurobiological Aspects of Functional Recovery in Major Depressive DisorderTrisha Chakrabarty, David Sarfati and Raymond W. Lam25. Diet and Depression: From Epidemiology to Novel TherapeuticsWolfgang Marx, Erin Hoare and Felice Jacka26. Physical Activity and Exercise as a Treatment of Depression: Evidence and Neurobiological MechanismBrendon Stubbs and Felipe Schuch27. Antidepressants and Suicidality—Controversies and Possible MechanismsJosef Witt-Doerring and Sanjay Mathew28. Altered GABAergic Function, Cortical Microcircuitry, and Information Processing in DepressionDwight F. Newton, Corey Fee, Yuliya S. Nikolova and Etienne Sibille29. Biomarker-Based Treatment Selection: A Precision Medicine Approach for DepressionJennifer L. Furman and Madhukar H. Trivedi30. Implications of Pharmacogenomics in Depression Pathophysiology and TreatmentForbes M.P., Jaksa P.
