Description
The Molecular Nutrition of Fats presents the nutritional and molecular aspects of fats by assessing their dietary components, their structural and metabolic effects on the cell, and their role in health and disease. Subject areas include molecular mechanisms, membranes, polymorphisms, SNPs, genomic wide analysis, genotypes, gene expression, genetic modifications and other aspects. The book is divided into three sections, providing information on the general and introductory aspects, the molecular biology of the cell, and the genetic machinery and its function. Topics discussed include lipid-related molecules, dietary lipids and lipid metabolism, high fat diets, choline, cholesterol, membranes, trans-and saturated fatty acids, and lipid rafts.Other sections provide comprehensive discussions on G protein-coupled receptors, micro RNA, transcriptomics, transcriptional factors, cholesterol, triacylglycerols, beta-oxidation, cholesteryl ester transfer, beta-oxidation, lysosomes, lipid droplets, insulin mTOR signaling and ligands, and more.- Summarizes molecular nutrition in health as related to fats- Discusses the impact of fats on cancer, heart disease, dementia, and respiratory and intestinal disease- Includes preclinical, clinical and population studies- Covers the genome, the whole body and whole communities- Includes key facts, a mini dictionary of terms and summary points
Table of Contents
Section 1: General and Introductory Aspects1. Intestinal health and bioactive lipids2. C-reactive protein and plasma fatty acids: public health concerns and implications3. The role of a fatty acid chain elongase, Elovl,1 in zebrafish and implications fcor human kidney4. Dietary lipids and lipid metabolism: An overview5. Fatty acids use in neurological disease6. The Neurocan-cartilage intermediate layer protein NCAN-CILP2 region and plasma lipid levels7. Role of cholesterol on controlling membrane phospholipid asymmetry8. Adipose tissue and peritoneal dialysis9. Lipid biomarkers and cancer10. Absorption of dietary fat and their metabolism in enterocytes11. The lipid-lowering action of iodothyronines12. Dietary Omega-3s and Muscle Composition in adults13. An overview of cholesterol absorption14. Triacylglycerols and use of docosahexaenoic acid at the sn-2 position15. Safety of Docosahexaenoic acid (DHA) ethyl ester and implications for human studies16. Fish oil supplementation and depression17. Drugs to counter SFA-mediated lipointoxication18. Lipoprotein (a) [Lp(a)]19. Endoplasmic reticulum (ER) stress, and white adipose tissue lipolysis20. Trans-fat intake and behaviour21. Glycemic index meal feeding and lipid profiling22. Beef Fat23. Lipid pathway in liver cells and its modulation by dietary extractsSection 2: Molecular Biology of the Cell24. Subcellular organelles: lipid droplets25. Optimized omega-3 EPA:DHA 6:1 and pulmonary arterial hypertension26. Omega-3 fatty acids and epilepsy27. Docosahexaenoic acid (DHA): A dietary supplement with promising anticancer potential28. Periaortic adipose tissue in obesogenic diets29. Genomics, statins and lipid metabolism30. Cholesterol metabolism in atherosclerosis development31. Lipid metabolism in dyslipidemia and familial hypercholesterolemia32. Lipid Profile of Progenitor Cells33. Trans-fatty acids and mortality34. Saturated and monounsaturated fatty acids associate with development and prematurity35. Hedgehog signaling and liver lipid metabolism36. Cyclosporin A-Induced Dyslipidemia and LDL Receptors37. Hypoxia and adipose tissue lipid breakdown38. Intramyocellular fat storageSection 3: Genetic Machinery and Its Function39. Fatty acid binding protein 2 genes and public health implications for diabetes40. Transcriptional factor modulation by lipid peroxidation-derived aldehydes41. Heterogeneity of white adipose tissue42. Nomenclature, classes and functions of lipids and lipid-related molecules, Dietary lipids43. Lipid metabolism: an overview - The mitochondria as a site of fatty acid beta-oxidation44. Fatty acids, gut bacteria and immune cell function
