疼痛のエピジェネティクス Epigenetics of Chronic Pain

著者名：Bai, Guang (EDT)/Ren, Ke (EDT)

Academic Press（2018/10/29発売）

• 言語：ENG
• ISBN：9780128140703
• eISBN：9780128140710

Description

Epigenetics of Chronic Pain, Volume Nine, presents comprehensive information on the role of epigenetics in chronic pain sensitivity, providing a detailed, but accessible, view of the field from basic principles, to clinical application. Leading international researchers discuss essential mechanisms of chronic pain epigenetics, including the molecular processes of chromatin remodeling, histone modifications, and the microRNAs and noncoding RNAs involved in regulating genes tied to pain sensitivity. The influence of epigenetics in inflammatory, neuropathic, visceral and other pain models is examined, with data derived from epigenetic studies on peripheral and central mechanisms of pain sensitivity in animal models and clinical cases studies.The studies and case examples cited highlight therapeutic pathways of significance and next steps for researchers to develop epigenetic-based treatments for chronic pain. In recent years, epigenetic regulation of gene expression has been shown to play a central role in managing human pain sensitivity. Findings show that expression of many genes critical to increases or decreases in pain sensitivity are indeed regulated by DNA methylation and its enzymes, histone-involved chromatin remodeling, and noncoding RNAs, mainly microRNAs.- Compiles all known information on epigenetic regulation of chronic pain in one volume- Covers the basic functionality of epigenetic mechanisms involved in pain management, applications of recent research in understanding different types of chronic pain, and pathways for developing therapeutics- Leading international researchers from across academia, clinical settings, and the pharmaceutical industry discuss epigenetics in inflammatory, neuropathic, visceral, and other pain models in-depth- Enables clinicians, researchers, and pharmacologists to better understand and treat chronic pain

Table of Contents

1. Epigenetic tools in chronic pain studies2. Epigenetic regulation of peripheral macrophages in neuropathic pain3. Emphasizing histone-related chromatin remodeling in the central nervous system of animal models of chronic pain4. Role of histone modifications in chronic pain development5. Role of DNA Methylation in Chronic Pain6. Pain-induced chromatin modifications7. DNA Methylation/Demethylation Homeostasis and Various Pain Conditions8. Epigenetic Modulation of Visceral Pain9. Non-coding RNAs are new players in chronic pain10. Epigenetics of Chronic Visceral Nociception11.  An overview of epigenetic correlates of human chronic pain conditions