代謝表現型ハンドブック The Handbook of Metabolic Phenotyping

著者名：Lindon, John C. (EDT)/Nicholson, Jeremy K. (EDT)/Holmes, Elaine (EDT)

Elsevier（2018/10/04発売）

• 言語：ENG
• ISBN：9780128122938
• eISBN：9780128122945

Description

The Handbook of Metabolic Phenotyping is the definitive work on the rapidly developing subject of metabolic phenotyping. It explores in detail the wide array of analytical chemistry and statistical modeling techniques used in the field, coupled with surveys of the various application areas in human development, nutrition, disease, therapy, and epidemiology to create a comprehensive exploration of the area of study. It covers recent studies that integrate the various -omics data sets to derive a systems biology view. It also addresses current issues on standardization, assay and statistics validation, and data storage and sharing. Written by experts with many years of practice in the field who pioneered many of the approaches widely used today, The Handbook of Metabolic Phenotyping is a valuable resource for postgrads and research scientists studying and furthering the field of metabolomics.- Contains theoretical and practical explanations of all the main analytical chemistry techniques used in metabolic phenotyping- Explores, in detail, the many diverse statistical approaches used in the field- Offers practical tips for successfully conducting metabolic phenotyping studies- Features reviews of all of the various fields of activity relating to human studies

Table of Contents

1. An Overview of Metabolic Phenotyping and Its Role in Systems Biology2. NMR Spectroscopy Methods in Metabolic Phenotyping3. The Role of Ultra Performance Liquid Chromatography-Mass Spectrometry in Metabolic Phenotyping4. GC-MS-Based Metabolic Phenotyping5. Metabolic Phenotyping Using Capillary Electrophoresis Mass Spectrometry6. Supercritical Fluid Chromatography for Metabolic Phenotyping: Potential and Applications7. The iKnife: Development and Clinical Applications of Rapid Evaporative Ionization Mass Spectrometry8. Univariate Statistical Modeling, Multiple Testing Correction, and Visualization in Metabolome-Wide Association Studies9. Multivariate Statistical Methods for Metabolic Phenotyping10. Data-Driven Visualizations in Metabolic Phenotyping11. Big Data and Databases for Metabolic Phenotyping12. Progress in Standardization of Metabolic Phenotyping Data13. Conception, Implementation and Operation of Large-Scale Metabolic Phenotyping Centres: Phenome Centres14. Applications of Metabolic Phenotyping in Pharmaceutical Research and Development15. Metabolic Phenotyping in Nutrition Research16. Metabolic Phenotyping in Clinical Practice17. Applications of Metabolic Phenotyping in Epidemiology18. Influence of the Human Gut Microbiome on the Metabolic Phenotype19. Linking Metabolic Phenotyping and Genomic Information20. Metabolic Phenotyping: History, Status, and Prospects