Description
Perinatal Stem Cells provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources, such as amniotic fluid, placenta and placental membranes, the umbilical cord and Wharton's jelly. It's compiled by leading experts in the field, offering readers detailed insights into sources of perinatal stem cells and their potential for disease treatment. Therapeutic applications of perinatal stem cells include the treatment of in utero and pregnancy related diseases, cardiac disease, liver disease, pulmonary disease, inflammatory diseases, for hematopoietic regeneration, and for neural protection after stroke or traumatic brain injury.In addition, the rapid advance in clinical translation and commercialization of perinatal stem cell therapies is highlighted in a section on Clinical and Industry Perspective which provides insight into the new opportunities and challenges involved in this novel and exciting industry.- Explores current clinical and pre-clinical application of stem cells derived from perinatal sources- Offers detailed insight into sources of perinatal stem cells and their potential for disease treatment- Discusses progress in the manufacturing, banking and clinical translation of perinatal stem cells- Edited by a world-renowned team to present a complete story of the development and promise of perinatal stem cells
Table of Contents
Section I. Amniotic Fluid-Derived Stem Cells1. In utero therapy for congenital disorders using amniotic fluid stem cells2. The Amniotic Fluid Stem Cell Secretome: at the Heart of Regeneration3. Transplantation of Amniotic Fluid-Derived Neural Stem Cells4. Stroke therapy: the potential of amniotic fluid-derived stem cells5. Vascular formation by human perinatal stem cells6. Amniotic Fluid Stem Cells for Kidney RegenerationSection II. Placental and Placental Membrane-Derived Stem Cells7. Placental mesenchymal stem cells for cellular cardiomyoplasty8. Heterogeneous functions of perinatal mesenchymal stromal cells require a preselection before their banking for clinical use9. Defining the fetal stem cell niche in the human placenta10. Banking placental tissue hematopoietic stem cells and mesenchymal stem cells for clinical use11. Immuno-modulatory mechanisms of placental stem cells12. Amnion Membrane Allograft for Regenerative Medicine13. Perinatal cells and biomaterials for wound healing14. Placental Stem Cells15. Therapeutic Effect of Extracellular Vesicles Derived from Adult/Perinatal Human Mesenchymal Stem CellsSection III. Umbilical Cord-Derived Cells16. Ex-vivo Expansion of Cord Blood Stem Cells17. Cord Blood Transplantation: Therapeutic Use of Perinatal Stem Cells18. Autologous Human Cord Blood as a Treatment for Traumatic Brain Injury in Children19. Phenotypic and Functional Characterization Perinatal Stem Cells Isolated from Umbilical Cord Tissue20. Mesenchymal stromal cells from Wharton's jelly (WJ-MSCs): coupling their hidden differentiative program with their frank immunomodulatory phenotype21. Regeneration of ischemic cardiovascular damage using Jelly Wharton as an unlimited source of therapeutic stem cells22. Phenotype with Focused Paracrine Fractions: Effecting Future Phenotype with Focused Paracrine FractionsSection IV. Clinical and Industry Perspective23. Clinical Translation of Perinatal Stem Cell Therapy24. Current Clinical Trials utilizing Perinatal Stem Cells – A Review25. Review Of Processing Technology and Techniques for Perinatal Stem Cells Banking And Clinical Applications26. Clinical Development And Commercialization Of Placenta-Derived Cell Therapy27. How the patent landscape has changed28. The Need for Better Assays to Predict the Effectiveness of Tissue Stem Cell Treatments
